Measuring Preferences for Fertility in Breast Cancer for a Decision Aid

测量乳腺癌患者的生育偏好以帮助决策

• 批准号: 7315817
• 负责人: CHRISTINE MARY DUFFY
• 金额: $ 13.23万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7315817
• 关键词: Abate; Advocate; Affect; Benefits and Risks; Biological Preservation; Cancer Patient; Cancer Survivor; Decision Aid; Decision Making; Decision Modeling; Diagnosis; Face; Fertility; Fertility Preferences; Focus Groups; Future; Glean; Health; Invasive; Knowledge; Life; Measures; Methods; Modeling; Morbidity - disease rate; Operative Surgical Procedures; Outcome; Patient Preferences; Patients; Population; Process; Quality of life; Radiation therapy; Recurrence; Research; Risk; Sampling; Testing; Time; Utility Theories; Woman; aged; base; cancer therapy; chemotherapy; malignant breast neoplasm; mortality; preference; time use; tool

DESCRIPTION (provided by applicant): Women diagnosed with breast cancer must not only face a variety of invasive, lengthy treatments that can involve surgery, chemotherapy, and radiation therapy, they also often face a threat to their fertility as a result of these treatments. Young women who have undergone cancer treatment consistently identify fertility concerns among the most troubling issues and these concerns do not abate with time. Options for preserving fertility are available, but decisions to pursue available options complicated as these decisions potentially affect a woman's risk for recurrence, mortality, and her quality of life. When there is no single option to be advocated, it is imperative to incorporate a woman's preferences into the decision making process. Decision aids can assist with difficult decisions that involve evaluating uncertain scientific evidence and weighing the benefits and risks of treatment options. They have been found to be acceptable to patients and feasible to implement. The Specific Aims of this project are to: 1) Characterize the decision making needs of young (aged 21-45) breast cancer patients regarding fertility preservation by conducting focus groups that explore the knowledge, personal risk information, and weighing of competing factors; 2) Develop a decision analytic model of the fertility preservation decision in women with breast cancer, based on information gleaned from qualitative studies; 3) Measure the preferences for fertility preservation in young women diagnosed with breast cancer, using the Time Trade-Off method derived from expected utility theory; 4) Develop a decision aid for the fertility preservation decision using the decision model; 5) Pilot test the decision aid in a small sample of young women diagnosed with breast cancer who are at risk of fertility loss and are facing the fertility preservation decision. This research will be the first decision aid for fertility preservation decisions in a breast cancer population that specifically incorporates patient preferences. The information gained from this research will be invaluable in developing future tools for women to make decisions regarding fertility and will have a beneficial effect on breast cancer survivors' lives, and relieve morbidity associated with cancer treatments.

描述（由申请人提供）：被诊断患有乳腺癌的女性不仅必须面临各种侵入性、漫长的治疗，包括手术、化疗和放射治疗，而且她们的生育能力也经常因这些治疗而受到威胁。接受过癌症治疗的年轻女性一致认为生育问题是最令人不安的问题之一，而且这些问题不会随着时间的推移而减弱。保留生育能力的选择是可用的，但寻求可用选择的决定很复杂，因为这些决定可能会影响女性的复发风险、死亡率和生活质量。当没有单一的选择可供提倡时，必须将女性的偏好纳入决策过程。决策辅助工具可以帮助做出困难的决策，包括评估不确定的科学证据并权衡治疗方案的益处和风险。人们发现它们是患者可以接受的并且可以实施。该项目的具体目标是： 1) 通过开展焦点小组探索知识、个人风险信息和权衡竞争因素，描述年轻（21-45 岁）乳腺癌患者在保留生育能力方面的决策需求； 2) 根据定性研究收集的信息，开发乳腺癌女性生育力保留决策的决策分析模型； 3）使用基于预期效用理论的时间权衡方法测量被诊断患有乳腺癌的年轻女性对保留生育能力的偏好； 4）利用决策模型开发生育力保留决策的决策辅助工具； 5) 在一小部分被诊断患有乳腺癌的年轻女性中对决策辅助进行试点测试，这些女性面临生育能力丧失的风险并面临保留生育能力的决定。这项研究将成为乳腺癌人群中第一个专门考虑患者偏好的生育力保存决策的决策辅助工具。从这项研究中获得的信息对于开发未来的工具来帮助女性做出有关生育的决定将是非常宝贵的，并将对乳腺癌幸存者的生活产生有益的影响，并减轻与癌症治疗相关的发病率。