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Measuring Preferences for Fertility in Breast Cancer for a Decision Aid

测量乳腺癌患者的生育偏好以帮助决策

基本信息

批准号：
8129805
负责人：
CHRISTINE MARY DUFFY
金额：
$ 13.23万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-05 至 2012-12-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Women diagnosed with breast cancer must not only face a variety of invasive, lengthy treatments that can involve surgery, chemotherapy, and radiation therapy, they also often face a threat to their fertility as a result of these treatments. Young women who have undergone cancer treatment consistently identify fertility concerns among the most troubling issues and these concerns do not abate with time. Options for preserving fertility are available, but decisions to pursue available options complicated as these decisions potentially affect a woman's risk for recurrence, mortality, and her quality of life. When there is no single option to be advocated, it is imperative to incorporate a woman's preferences into the decision making process. Decision aids can assist with difficult decisions that involve evaluating uncertain scientific evidence and weighing the benefits and risks of treatment options. They have been found to be acceptable to patients and feasible to implement. The Specific Aims of this project are to: 1) Characterize the decision making needs of young (aged 21-45) breast cancer patients regarding fertility preservation by conducting focus groups that explore the knowledge, personal risk information, and weighing of competing factors; 2) Develop a decision analytic model of the fertility preservation decision in women with breast cancer, based on information gleaned from qualitative studies; 3) Measure the preferences for fertility preservation in young women diagnosed with breast cancer, using the Time Trade-Off method derived from expected utility theory; 4) Develop a decision aid for the fertility preservation decision using the decision model; 5) Pilot test the decision aid in a small sample of young women diagnosed with breast cancer who are at risk of fertility loss and are facing the fertility preservation decision. This research will be the first decision aid for fertility preservation decisions in a breast cancer population that specifically incorporates patient preferences. The information gained from this research will be invaluable in developing future tools for women to make decisions regarding fertility and will have a beneficial effect on breast cancer survivors' lives, and relieve morbidity associated with cancer treatments.

描述（由申请人提供）：被诊断患有乳腺癌的妇女不仅要面对各种侵入性的、漫长的治疗，包括手术、化疗和放射治疗，而且由于这些治疗，她们的生育能力经常受到威胁。接受过癌症治疗的年轻女性一直认为生育问题是最令人不安的问题之一，而且这种担忧并没有随着时间的推移而减弱。保留生育能力的选择是可行的，但是选择可行的选择是复杂的，因为这些决定可能会影响妇女的复发风险、死亡率和生活质量。当没有单一的选择可以提倡时，就必须将妇女的偏好纳入决策过程。决策辅助工具可以帮助做出涉及评估不确定的科学证据和权衡治疗方案的利益和风险的困难决定。它们已被发现为患者所接受，并且可行实施。该项目的具体目的是：1)通过开展焦点小组，探讨知识、个人风险信息和权衡竞争因素，表征年轻（21-45岁）乳腺癌患者在保留生育能力方面的决策需求；2)基于定性研究收集的信息，建立乳腺癌患者生育能力保留决策的决策分析模型；3)利用期望效用理论衍生的时间权衡法，测量年轻乳腺癌女性对保留生育能力的偏好；4)利用该决策模型开发生育保留决策辅助工具；5)在一小部分被诊断为乳腺癌、有生育能力丧失风险并面临保留生育能力决定的年轻女性中，对决策辅助进行试点测试。这项研究将是第一个在乳腺癌人群中明确纳入患者偏好的生育能力保留决策的决策辅助。从这项研究中获得的信息将是无价的，有助于开发未来的工具，帮助妇女做出有关生育的决定，并将对乳腺癌幸存者的生活产生有益的影响，并减轻与癌症治疗相关的发病率。