Adherence Among Older Women with Breast Cancer

患有乳腺癌的老年女性的依从性

• 批准号: 7253371
• 负责人: SHARON Hermes GIORDANO
• 金额: $ 13.61万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253371
• 关键词: Address; Adherence; Adjuvant; Adjuvant Chemotherapy; Adjuvant Radiotherapy; Adjuvant Therapy; Affect; Breast Cancer Treatment; Cancer Patient; Caring; Characteristics; Cognition; Communities; Comorbidity; Condition; Data; Data Analyses; Data Collection; Databases; Dementia; Development; Diagnosis; Disease; Effectiveness; Ensure; Ethnic Origin; Geography; Goals; Health Services; Intervention; K-Series Research Career Programs; Knowledge; Link; Medical Oncologist; Medicare; Mental Depression; Mentors; Motivation; Operative Surgical Procedures; Oral; Outcome; Patient Noncompliance; Patients; Pattern; Physicians; Population; Practice Guidelines; Prospective Studies; Qualifying; Radiation therapy; Randomized Clinical Trials; Reading; Research; Research Personnel; Risk; Sampling; Socioeconomic Status; Standards of Weights and Measures; Therapeutic Clinical Trial; Training; Treatment Protocols; United States; Woman; base; career; chemotherapy; compliance behavior; experience; hormone therapy; improved; malignant breast neoplasm; mortality; neoplasm registry; older women; skills; statistics

DESCRIPTION (provided by applicant): The objective of this career development award is to provide Dr. Sharon Giordano with the experience and knowledge necessary to become an independent health services researcher in the field of breast cancer. Dr. Giordano, who is a medical oncologist and MPH candidate, will accomplish this goal through a combination of directed reading, seminars, coursework, and mentored research. A highly qualified team of mentors will supervise her training and ensure that she meets her goals. Dr. Giordano will be examining adherence to a standard course of adjuvant treatment among older women with breast cancer using two different approaches: secondary data analyses using the SEER-Medicare database and primary data collection. The specific aims of this proposal are: 1 ) to describe lack of adherence to chemotherapy and radiotherapy in a population-based sample of older women with breast cancer; 2) to determine the effect of specific comorbidities as well as patient, physician, and environmental characteristics on adherence to chemotherapy and radiotherapy; and 3) to prospectively identify factors, including the potentially unrecognized comorbidities of depression and dementia, that affect adherence to therapy in older women with breast cancer. The first two specific aims will be accomplished using the population-based SEER-Medicare database, and the third specific aim through a prospective study. The proposed research will provide important knowledge regarding the patterns and predictors of adherence to adjuvant therapy among older women. In addition, these studies will provide the applicant with expertise in the use of cancer registry data and claims data, in primary data collection, and in data analysis. The proposed studies and career development activities will provide the applicant with the skills to develop into an independent investigator.

描述（由申请人提供）：该职业发展奖的目的是为 Sharon Giordano 博士提供成为乳腺癌领域独立健康服务研究员所需的经验和知识。 Giordano 博士是一名医学肿瘤学家和公共卫生硕士候选人，他将通过定向阅读、研讨会、课程作业和指导研究的结合来实现这一目标。 高素质的导师团队将监督她的培训并确保她实现目标。 Giordano 博士将使用两种不同的方法来检查老年乳腺癌女性对标准辅助治疗疗程的遵守情况：使用 SEER-Medicare 数据库的二次数据分析和主要数据收集。 本次活动的具体目标 建议是： 1) 描述在患有乳腺癌的老年妇女的人群样本中缺乏对化疗和放疗依从性的情况； 2) 确定特定合并症以及患者、医生和环境特征对化疗和放疗依从性的影响； 3) 前瞻性地确定影响老年乳腺癌女性坚持治疗的因素，包括潜在未被识别的抑郁症和痴呆症合并症。 前两个具体目标将使用基于人群的 SEER-Medicare 数据库来实现，第三个具体目标将通过前瞻性研究来实现。 拟议的研究将提供有关老年妇女坚持辅助治疗的模式和预测因素的重要知识。 此外，这些研究将为申请人提供癌症登记数据和索赔数据的使用、主要数据收集和数据分析方面的专业知识。 拟议的研究和职业发展活动将为申请人提供发展成为独立研究者的技能。