UPR/MDACC: Partnership for Excellence in Cancer Research (2 of 2)

UPR/MDACC：癌症研究卓越合作伙伴关系（2 中的 2）

• 批准号: 10672313
• 负责人: SHARON Hermes GIORDANO
• 金额: $ 105.05万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10672313
• 关键词: Address; Advanced Malignant Neoplasm; Advocate; Affect; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Hospital; Career Mobility; Collaborations; Communities; Community Outreach; Comprehensive Cancer Center; Development; Diagnosis; Early Diagnosis; Economically Deprived Population; Education; Elements; Ensure; Evaluation; Faculty; Goals; Government; Grant; HIV; Hispanic; Hispanic Populations; Human Papilloma Virus Vaccination; Human Papilloma Virus-Related Malignant Neoplasm; Immunization Programs; Infection; Infrastructure; Institution; Interdisciplinary Study; Intervention; Joints; Laboratories; Latino Population; Laws; Link; Malignant Neoplasms; Medicine; Mission; Names; National Cancer Institute; National Cancer Program; Outcome Measure; Physicians; Prevention; Prevention program; Puerto Rico; Readiness; Research; Research Personnel; Research Project Grants; Resource Sharing; Risk Factors; Role; Science; Scientist; Students; Texas; Training; Translational Research; Translational Research Working Group; Underrepresented Minority; Universities; University of Texas M D Anderson Cancer Center; Vaccination; Vision; Work; anticancer research; cancer health disparity; cancer prevention; career; career development; design; disparity reduction; experience; health disparity; health equity; infection burden; infection risk; malignant stomach neoplasm; minority communities; multidisciplinary; outreach; population based; programs; socioeconomic disadvantage; success; survivorship; synergism; tool development; underserved community

OVERALL PROJECT SUMMARY / ABSTRACT This competitive renewal of the Partnership for Excellence in Cancer Research (Partnership) between the University of Puerto Rico (UPR) and the University of Texas MD Anderson Cancer Center (MDACC) will: 1) solidify, strengthen, and expand the relationship between UPR and MDACC; and 2) leverage the breadth and strengths of an experienced and integrated Partnership in transition of the UPR Comprehensive Cancer Center (UPRCCC) towards a long-term overall goal: recognition of UPRCCC as an NCI-designated cancer center. To address some of the most profound cancer health disparities in Puerto Rico and Texas, the Partnership will establish an Infection-Driven Malignancies Program for Advancing Careers and Translational Sciences (IMPACT). This application represents a partnership in which both institutions profit from sharing distinct expertise to mutually benefit in implementation of integrated team science, outreach, education and career development initiatives. To facilitate UPRCCC’s transition towards NCI-designation, the UPR PIs led the development of the specific aims with support of the MDACC PIs. The Specific Aims for the renewal are: 1) Develop a multidisciplinary research portfolio focused on health disparities derived from infection-driven malignancies; 2) Increase the number of Hispanic students pursuing careers in laboratory and population- based cancer research to produce a critical mass of clinicians, scientists, and physician-scientists, who specialize in cancer research, with emphasis on cancer health disparities in underrepresented minorities and underserved communities; 3) Strengthen sustainable collaborations among all the stakeholders to develop and promote key community outreach, education, and interventions aimed at reducing cancer rates and emphasizing vaccinations against malignancy linked infections, among Hispanic/Latino populations in PR, TX, and elsewhere; 4) Leverage strategic collaborations with NCI-designated cancer centers to augment the cancer research capacity of the UPR and the UPRCCC; and 5) Provide professional support and development tools through the a) Administration; b) Planning and Evaluation; and c) Shared Resources Cores designed to nurture and optimize the Partnership’s research, education, and outreach agendas in support of the long-term goal of an NCI-designated Cancer Center. Key elements of this application to advance the Partnership include: 1) Multidisciplinary collaborative research projects focused on IMPACT that represent stages of the translational research continuum; 2) A comprehensive cancer-focused training and career development core; 3) The development of a dual MD/MPH degree to address specific cancers disproportionately affecting Hispanic populations; 4) Outreach efforts to build, educate, and advocate for broad HPV vaccination programs; and 5) a DATAOmics Core that builds infrastructure. This initiative will strengthen the overall cancer research enterprise in infection-driven malignancies in both PR and TX, and will support the implementation of UPRCCC’s roadmap to submission of a Cancer Center Support Grant (P30) for NCI designation.

全面的 项目概要/摘要 癌症研究卓越合作伙伴关系（合作伙伴关系）的竞争性更新 波多黎各大学 (UPR) 和德克萨斯大学 MD 安德森癌症中心 (MDACC) 将：1) 巩固、加强和扩大普遍定期审议和 MDACC 之间的关系； 2）利用广度和 UPR 综合癌症中心转型过程中经验丰富且综合的合作伙伴关系的优势 (UPRCCC) 致力于实现长期总体目标：承认 UPRCCC 作为 NCI 指定的癌症中心。到 为了解决波多黎各和德克萨斯州一些最严重的癌症健康差异，该伙伴关系将 建立感染驱动的恶性肿瘤计划以促进职业发展和转化科学 （影响）。该应用程序代表了一种合作伙伴关系，两个机构通过共享不同的 在实施综合团队科学、外展、教育和职业方面互惠互利的专业知识 发展举措。为了促进 UPRCCC 向 NCI 指定过渡，UPR PI 领导了 在 MDACC PI 的支持下制定具体目标。更新的具体目标是： 1) 开发多学科研究组合，重点关注感染驱动的健康差异 恶性肿瘤； 2）增加在实验室和人口领域从事职业的西班牙裔学生的数量- 以癌症研究为基础，培养足够数量的临床医生、科学家和医师科学家，他们 专注于癌症研究，重点关注代表性不足的少数群体的癌症健康差异和 服务不足的社区； 3) 加强所有利益相关者之间的可持续合作，以开发和 促进旨在降低癌症发病率的关键社区外展、教育和干预措施 强调在波多黎各州、德克萨斯州、 以及其他地方； 4) 利用与 NCI 指定癌症中心的战略合作来增强 UPR 和 UPRCCC 的癌症研究能力； 5) 提供专业支持和发展 通过 a) 管理工具； b) 规划和评估； c) 共享资源核心旨在 培育和优化合作伙伴关系的研究、教育和推广议程，以支持长期目标 NCI 指定癌症中心的目标。该申请旨在推进合作伙伴关系的关键要素包括： 1) 侧重于 IMPACT 的多学科合作研究项目，代表了各个阶段 转化研究连续体； 2）以癌症为中心的全面培训和职业发展核心； 3) 开发医学博士/公共卫生硕士双学位，以解决不成比例影响的特定癌症 西班牙裔人口； 4) 建立、教育和倡导广泛的 HPV 疫苗接种计划的外展工作； 5) 构建基础设施的 DATAOmics 核心。这一举措将加强整体癌症研究 企业在 PR 和 TX 的感染驱动的恶性肿瘤，并将支持实施 UPRCCC 提交癌症中心支持补助金 (P30) 以获得 NCI 指定的路线图。

项目成果

A tutorial in genetic epidemiology and some considerations in statistical modeling.

• 发表时间: 2007
• 期刊: Puerto Rico health sciences journal
• 影响因子: 0.5
• 作者: E. Suárez;C. Sariol;A. Burguete;G. McLachlan

Human Papillomavirus Correlates With Histologic Anal High-Grade Squamous Intraepithelial Lesions in Hispanics With HIV.

• DOI: 10.1097/lgt.0000000000000416
• 发表时间: 2018-10
• 期刊: Journal of lower genital tract disease
• 影响因子: 3.7
• 作者: Medina-Laabes DT;Suarez-Perez EL;Guiot HM;Muñoz C;Colón-López V;Tirado-Gómez M;Ortiz AP
• 通讯作者: Ortiz AP

Promoting tobacco cessation and smoke-free workplaces through community outreach partnerships in Puerto Rico.

• DOI: 10.1353/cpr.2014.0032
• 发表时间: 2014
• 期刊: Progress in community health partnerships : research, education, and action
• 作者: Díaz-Toro EC;Fernández ME;Correa-Fernández V;Calo WA;Ortiz AP;Mejía LM;Mazas CA;Santos-Ortiz Mdel C;Wetter DW
• 通讯作者: Wetter DW

Seroepidemiology of viral hepatitis, HIV and herpes simplex type 2 in the household population aged 21-64 years in Puerto Rico.

• DOI: 10.1186/1471-2334-10-76
• 发表时间: 2010-03-23
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Pérez CM;Marrero E;Meléndez M;Adrovet S;Colón H;Ortiz AP;Soto-Salgado M;Albizu C;Torres EA;Suárez E
• 通讯作者: Suárez E

Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.

• DOI: 10.1016/j.jchromb.2014.12.021
• 发表时间: 2015-02-15
• 期刊: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
• 影响因子: 3
• 作者: Humphries-Bickley, Tessa;Castillo-Pichardo, Linette;Corujo-Carro, Francheska;Duconge, Jorge;Hernandez-O'Farrill, Eliud;Vlaar, Cornelis;Rodriguez-Orengo, Jose F.;Cubano, Luis;Dharmawardhane, Suranganie
• 通讯作者: Dharmawardhane, Suranganie