Evaluation of the Healing Factors and Characteristics of a novel Advanced Biological Wound Dressing Technology

慢性伤口愈合的机制以及先进的生物伤口敷料技术能够影响伤口愈合的方法仍然没有完全了解。通过临床前和临床研究更好地了解这些机制将使临床医生能够更好地管理复杂伤口，愈合这些伤口更快，复发的风险更低。这项研究项目将解决改善前，先进的生物伤口敷料技术的临床特征，并确定该技术中哪些成分和结构因素影响细胞迁移、细胞生长、血管生长和结缔组织重建，作为有助于伤口愈合的基本机制。通过本研究项目，可以更好地了解这些伤口愈合机制，以确保开发出进一步改进的技术来应对不愈合伤口的挑战。

Mechanisms for the healing of chronic wounds and the means by which advanced biological wound dressing technologies are able to influence wound healing are still not fully understood.Better understanding of these mechanisms through both pre-clinical and clinical studies will enable clinicians to better manage complex wounds, healing those wounds faster and with lower risk of recurrence.This research project will address the improved pre-clinical characterisation of an advanced biological wound dressing technology and determine which compositional and structural factors within the technology are influencing cell migration, cell growth, blood vessel growth and connective tissue reformation, as the fundamental mechanisms that contribute to wound healing.Through this research project, better knowledge of these wound healing mechanisms can be gained to ensure that further improved technologies are developed to meet the challenge of non-healing wounds.