Prescription Drug Abuse Among Club Drug Users

药物的非医疗使用在美国一直是一个长期存在的问题，自20世纪70年代以来，“俱乐部药物”的使用一直是青少年和年轻人的问题。最近的一个趋势是处方药侵入俱乐部文化，随之而来的是与滥用处方药有关的健康后果。由于他们的年轻和他们的倾向，混合多种药物在任何特定的药物狂欢，俱乐部吸毒者往往是一个高度脆弱的人口。在此背景下，本申请的具体目的是：1）招募750名18-39岁的治疗外处方药和俱乐部药物滥用者的样本，并在基线时评估其酒精和药物滥用发作和进展的生活史，以及当前酒精和处方药、俱乐部和其他药物使用的程度; 2）在6、12和18个月时，评估受访者的酒精和处方、俱乐部和其他药物使用的开始、进展和程度的变化; 3）在基线、6、12和18个月时，评估抽样药物使用者获得处方药物的机制; 4）在基线、6个月、12个月和18个月时，调查处方和俱乐部药物滥用的数量、频率、类型和持续时间对该人群健康和社会后果的性质和程度的影响，包括：性冒险和胁迫;药物相互作用和过量;慢性药物使用;日常活动受损;身体问题;心理健康问题;和法律的问题;以及5）检查性别和其他潜在相关因素（性身份、性史、当前性行为、药物史和当前药物使用）对处方、俱乐部和其他药物滥用的发作、进展和程度以及健康和社会后果的性质和程度的影响。研究样本将反映迈阿密人口的种族/民族分布：30%的白色/盎格鲁人，50%的西班牙裔和20%的非洲裔美国人，50%的女性和50%的男性的性别分布。将使用各种统计技术来描述人口、俱乐部文化中处方药和其他药物使用的流行病学以及相关后果的性质和流行程度。短期目标是描述处方药滥用/俱乐部药物使用的变化性质及其在迈阿密俱乐部文化中的后果。一个更广泛的长期目标是更好地了解目前滥用处方药的模式及其对俱乐部文化的入侵，以便制定战略，减少迈阿密和其他社区滥用和转移这些药物。这些战略和政策最终可能会减少处方药的滥用和转移，并使其更容易提供给患者。

DESCRIPTION (provided by applicant): The non-medical use of Pharmaceuticals has been a long-standing problem in the United States, and since the 1970s the use of "club drugs" has been a problem among adolescents and young adults. A recent trend has been the incursion of prescription drugs into the club culture, with the concomitant health consequences associated with their abuse. Because of their young age and their tendency to mix numerous drugs during any given drug binge, club drug users tend to be a highly vulnerable population. Within this context, the specific aims of this application are to; 1) recruit a sample of 750 out-of-treatment prescription and club drugs abusers ages 18-39 and at baseline assess their life histories of alcohol and drug abuse onset and progression, and extent of current alcohol and prescription, club and other drug use; 2) at 6, 12 and 18 months, assess changes in onset, progression, and extent of respondents' alcohol and prescription, club and other drug use; 3) at baseline, 6, 12 months and 18 months, assess the mechanisms of access to prescription drugs among the sampled drug users; 4) at baseline, 6, 12 and 18 months, investigate the impact of quantity, frequency, types and duration of prescription and club drug abuse on the nature and extent of health and social consequences within this population, including: sexual risk-taking and coercion; drug interactions and overdose; chronic drug use; impairment of daily activities; physical problems; mental health problems; and legal problems; and 5) examine the impact of gender and other potential correlates (sexual identity, sexual history, current sexual behaviors, drug history, and current drug use) on onset, progression, and extent of prescription, club and other drug abuse and the nature and extent of health and social consequences. The study sample will reflect the race/ethnic distribution of the Miami population: 30 percent white/Anglo, 50 percent Hispanic, and 20 percent African-American, with a gender distribution of 50 percent female and 50 percent male. A variety of statistical techniques will be used to describe the population, the epidemiology of prescription and other drug use in the club culture, and the nature and prevalence of related consequences. The short-term objectives are to describe the changing nature of prescription drug abuse/club drug use and their consequences in the Miami club culture. A broader long-term goal is to better understand current patterns of the abuse of prescription drugs and their incursion into the club culture, in order that strategies can be developed for reducing the abuse and diversion of these drugs in Miami and other communities. Such strategies and policies may ultimately reduce the abuse and diversion of prescription drugs, as well as make them more readily available to the patients for whom they are intended.