Role of endogenous vanilloids and cannabinoids in pain
Role of endogenous vanilloids and cannabinoids in pain
批准号:
7485422
负责人:
J. Michael Walker
金额:
$3.75万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-03-01 至 2010-02-28
关键词:
AcidsAddressAffinityAmidesArachidonic AcidsBindingBiologicalBiological AssayBiologyBos taurusBrainCannabinoidsCapsaicinCarrageenanCattleCellsChemicalsClassConditionCorpus striatum structureCytochrome P450DataDopaDopamineEdemaEndocannabinoidsEnvironmentEnzymesFamilyFatty AcidsFire - disastersGoalsHyperalgesiaInflammationInflammatoryInjection of therapeutic agentKnockout MiceLaboratoriesLeftLeukotriene ReceptorLeukotrienesLigandsLipidsLipoxygenaseLocationMechanical StimulationMediatingMiningMolecularNervous system structureNeuronsNociceptionNumbersPainPathway interactionsPerceptionPharmacologyPharmacotherapyPhysiologicalPlayPropertyProstaglandin-Endoperoxide SynthasePublic HealthResearchResponse to stimulus physiologyRodentRoleSignal PathwaySignal TransductionSignaling MoleculeSiteSkinSpinalSpinal CordSpinal GangliaStructureStructure-Activity RelationshipSystemTRPV1 geneTissuesVanilloidWalkersanandamidebasecannabinoid receptorcapsaicin receptorcyclooxygenase 1drug developmentimprovedin vivomidbrain central gray substancenovelpain inhibitionreceptorrelating to nervous systemresearch studysize
中文摘要
对身体产生的促痛和抗伤害性分子的研究可能会产生重要的靶点
改善了疼痛的治疗。最近一个很有前途的研究途径是阐明
脂肪酸酰胺类脂类信号分子的生物学效应。建议数
实验集中在N-酰基多巴胺的表征上,N-酰基多巴胺是一种新的脂肪酸酰胺类化合物,可以
作为香草素和/或大麻素受体的信号配基。由于大麻素的激活
受体通常抑制疼痛,而香草素受体的激活(如辣椒素)通常
1
增加对疼痛的敏感性,N-酰基多巴胺可能内源性地起到促进或抑制疼痛的作用。我们
假设这些分子的作用取决于它们形成的位置和
蜂窝环境的状态。因此,我们计划调查这些化合物在
神经系统内的不同部位以及各种生理和病理生理学的影响
炎症等条件对其形成和生物活性的影响。除了检测大麻素和
香草素机制,我们计划检查我们在体内观察到的NADA的氧化代谢物。这个
该提案旨在阐明内源性N-酰基多巴胺及其氧合的生物学和功能
代谢物,以加强我们对这类新兴分子的理解,这可能是
对疼痛的感知和调节很重要。更好地理解这一系统可能会产生新的
旨在治疗疼痛和/或炎症的药物开发的目标。
英文摘要
The study of pro- and anti-nociceptive molecules produced by the body may yield important targets for
improved treatments of pain. A recent and promising avenue of researchhas been the elucidation of the
biological effects of a family of lipid signalling molecules referredto as fatty acid amides. The proposed
experiments focus on the characterization of N-acyldopamines, a novel group of fatty acid amides that may
serve as signalling ligands for the vanilloid and/or cannabinoid receptors. Since activation of cannabinoid
receptors typically suppresses pain, while activation of vanilloid receptors (e.g. by capsaicin) typically
1
heightens sensitivity to pain, N-acyldopamines may serve endogenously to facilitate or dampen pain. We
hypothesize that the actions of these molecules depend on the locations at which they are formed and the
state of the cellular environment. Hence, we plan to investigate the occurrence of these compounds at
various sites within the nervous system and the effect of various physiological and pathophysiological
conditions such as inflammation on their formation and bioactivity. In addition to examining cannabinoid and
vanilloid mechanisms, we plan to examine oxygenated metabolites of NADA that we observed in vivo. The
proposal aims to elucidate the biology and function of endogenous N-acyldopamines and their oxygenated
metabolites in order to enhance our understanding of this emerging class of molecules, which may be
important to the perception and modulation of pain. A better understanding of this system may yield novel
targets for drug development aimed at treating pain and/or inflammation.
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会议论文
Role of endogenous vanilloids and cannabinoids in pain
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批准号:7050563
-
项目类别:
-
资助金额:$32.03万
-
财政年份:2005
-
负责人:J. Michael Walker
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依托单位:
Role of endogenous vanilloids and cannabinoids in pain
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批准号:6930256
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项目类别:
-
资助金额:$34.09万
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财政年份:2005
-
负责人:J. Michael Walker
-
依托单位:
Role of endogenous vanilloids and cannabinoids in pain
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批准号:7195065
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项目类别:
-
资助金额:$31.1万
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财政年份:2005
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负责人:J. Michael Walker
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依托单位:
LABORATORY PRIMATE NEWSLETTER: PSYCH WELL BEING
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批准号:6982637
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项目类别:
-
资助金额:$6.57万
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财政年份:2003
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6719041
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项目类别:
-
资助金额:$21.8万
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财政年份:2000
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6350539
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项目类别:
-
资助金额:$30.58万
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财政年份:2000
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:7004889
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项目类别:
-
资助金额:$11.52万
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财政年份:2000
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6051687
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项目类别:
-
资助金额:$32.46万
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财政年份:2000
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6628355
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项目类别:
-
资助金额:$32.35万
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财政年份:2000
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负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6597375
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项目类别:
-
资助金额:$5.0万
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财政年份:2000
-
负责人:J. Michael Walker
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依托单位:
PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
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批准号:6497830
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项目类别:
-
资助金额:$31.41万
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财政年份:2000
-
负责人:J. Michael Walker
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依托单位:
PRECIPITATED CANNABINOID WITHDRAWAL
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批准号:2803611
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项目类别:
-
资助金额:$5.83万
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财政年份:1997
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负责人:J. Michael Walker
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依托单位:
PRECIPITATED CANNABINOID WITHDRAWAL
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批准号:2882614
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项目类别:
-
资助金额:$25.32万
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财政年份:1997
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负责人:J. Michael Walker
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依托单位:
PRECIPITATED CANNABINOID WITHDRAWAL
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批准号:2668170
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项目类别:
-
资助金额:$20.1万
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财政年份:1997
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负责人:J. Michael Walker
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依托单位:
PRECIPITATED CANNABINOID WITHDRAWAL
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批准号:2013658
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项目类别:
-
资助金额:$21.24万
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财政年份:1997
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负责人:J. Michael Walker
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依托单位:
SIGMA RECEPTORS AND DOPAMINE NEUROTRANSMISSION
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批准号:2377424
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项目类别:
-
资助金额:$18.97万
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财政年份:1996
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负责人:J. Michael Walker
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依托单位:
SIGMA RECEPTORS AND DOPAMINE NEUROTRANSMISSION
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批准号:2123503
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项目类别:
-
资助金额:$20.19万
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财政年份:1996
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负责人:J. Michael Walker
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依托单位:
SIGMA RECEPTORS AND DOPAMINE NEUROTRANSMISSION
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批准号:2654383
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项目类别:
-
资助金额:$19.71万
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财政年份:1996
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负责人:J. Michael Walker
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依托单位:
SIGMA RECEPTORS AND DOPAMINE NEUROTRANSMISSION
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批准号:2860034
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项目类别:
-
资助金额:$2.5万
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财政年份:1996
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负责人:J. Michael Walker
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依托单位:
NEUROLOGICAL BASIS OF PAIN--ROLE OF CANNABINOIDS
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批准号:2416364
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项目类别:
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资助金额:$19.76万
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财政年份:1995
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负责人:J. Michael Walker
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依托单位:
海外基金