Gammacell-40 Exactor Research Irradiator

Gammacell-40 Exactor 研究辐照器

• 批准号: 7212058
• 负责人: PHILLIP SCOTT
• 金额: $ 40.74万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-08 至 2008-06-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7212058
• 关键词: Animal Experimentation; Animals; Area; Arts; Bone Marrow; Chimera organism; Commit; Contract Services; Dose-Rate; Faculty; Funding; Funding Applicant; Housing; Immune response; Immunologic Deficiency Syndromes; Individual; Laboratories; Laboratory Research; Maintenance; Modeling; Mus; Pennsylvania; Research; Research Personnel; Rodent; Schools; Security; Services; Stem cells; Universities; Veterinary Medicine; Veterinary Schools; Wages; animal facility; base; day; design; human disease; instrument; irradiation; medical schools; pathogen; programs; reconstitution; research study; tumor

DESCRIPTION (provided by applicant): Funds are requested for a MDS Nordian Inc. Gammacell-40 Exactor Self-contained Low Dose Rate Research animal (rodent) irradiator to support the ongoing NIH-funded individual-initiated research programs in a new state of the art animal facility located within a recently erected research building (Hill Pavilion) on the campus of the University of Pennsylvania School of Veterinary Medicine. Ten core laboratories comprise the list of the major users of the requested instrument. Each will have laboratories in either the Hill Pavilion or the adjacent research laboratories at the Penn Vet School and all of them will house their mice and perform ongoing experiments requiring whole animal irradiation and extended maintenance of irradiated animals in ongoing experiments in the animal facility in the Hill Pavilion. These core laboratories will constitute the majority (>70%) of the usage of the irradiator by the School of Veterinary Medicine. There is a group of additional Veterinary School faculty that will utilize this instrument on an infrequent (<5%) basis. In addition, since the vivarium in Hill will be shared with the School of Medicine, there will be substantial usage by NIH-funded faculty from University of Pennsylvania School of Medicine who will occupy part of the new animal facility in the Hill Pavilion (25%). A specific need for this instrument arises because the new animal facility in which the animals of the core user group are housed is a closed facility in which animals taken to other buildings for irradiation cannot be returned to the investigator's designed area. As a consequence, it is impossible to perform long-term experiments requiring maintaining the animals beyond a single day after irradiation, or that require comparison of irradiated and non-irradiated experimental groups. As detailed in the project descriptions, these include irradiated, auto-reconstituting models, bone marrow chimeras, induction of immunodeficiency, among others. The University of Pennsylvania School of Veterinary Medicine has already made a significant financial commitment to support the procurement of this instrument, by constructing the room in which the irradiator will be housed. In addition, the School has committed funds for the ongoing service contract to maintain and service the instrument, and will provide salary support for a supervisor. The University will provide support for security. The installation of the Gammacell-40 in the Hill Pavilion vivarium will make possible studies that will elucidate immune responses to pathogens and tumors, as well as studies of stem cells. Each of these will advance our understanding of human diseases.

描述（由申请人提供）：资金要求为MDS诺迪安公司。Gammacell-40挤压机自给式低剂量率研究动物（啮齿动物）辐照器，用于支持正在进行的NIH资助的个人发起的研究项目，该项目位于宾夕法尼亚大学兽医学院校园内最近建造的研究大楼（Hill Pavilion）内的最先进的动物设施中。10个核心实验室构成所要求仪器的主要用户名单。每个实验室都将在Hill Pavilion或Penn Vet School的相邻研究实验室中设有实验室，所有实验室都将容纳小鼠，并在Hill Pavilion的动物设施中进行持续实验，需要对整个动物进行辐照并延长辐照动物的维护时间。这些核心实验室将占兽医学院辐照器使用量的大部分（>70%）。有一组额外的兽医学院教师将很少（<5%）使用这种仪器。此外，由于希尔的动物园将与医学院共享，因此来自宾夕法尼亚大学医学院的NIH资助的教师将大量使用希尔馆的新动物设施（25%）。对该仪器的特殊需求是因为核心用户组动物所处的新动物设施是一个封闭设施，其中被带到其他建筑物进行辐照的动物不能返回研究者的设计区域。因此，不可能进行需要在照射后维持动物超过一天的长期实验，或者需要比较照射和非照射实验组的长期实验。正如项目说明中所详述的，其中包括辐照、自动重建模型、骨髓嵌合体、诱导免疫缺陷等。宾夕法尼亚大学兽医学院已经做出了重大的财政承诺，通过建造将容纳辐照器的房间来支持该仪器的采购。此外，学校已承诺为正在进行的服务合同提供资金，以维护和维修仪器，并将为主管提供工资支持。大学将提供安全支持。Gammacell-40在Hill Pavilion动物园的安装将使阐明对病原体和肿瘤的免疫反应的研究以及干细胞的研究成为可能。这些都将促进我们对人类疾病的了解。