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Acquisition of a 500 MHz NMR Spectrometer

购买 500 MHz NMR 波谱仪

基本信息

批准号：
7216575
负责人：
WILLIAM C BRACKEN
金额：
$ 50万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2009-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In this proposal, funds are requested to acquire a 500 MHz NMR spectrometer to support biomedical research at Weill Medical College of Cornell University. The instrument will directly support 16 NIH funded research grants and serve as a core resource for the medical college. Currently, the university has one NMR spectrometer dedicated for NMR structural analysis of proteins. There is a growing need at Weill-Cornell for analysis of synthetic compounds, natural products and small peptides for a variety of biological and medicinal studies. The requested instrument will significantly reduce the burden on the sole spectrometer, provide analytical capability for biological and synthetic chemistry, and support the newly established Chemical Synthesis Core facility. The NMR spectrometer will be optimized for both small molecule and peptide studies. The NMR will include an inverse 1H/13C/15N probe with three radio frequency channels enabling triple resonance experiments. The instrument will have capabilities that do not currently exist at Weill-Cornell and are unavailable locally. These include: 1) a broad-band probe for direct detection of 1H, 19F, 31P, 11B, 13C, 23Na, and 15N; 2) a multi-sampler for automated sample insertion and data acquisition; and 3) an expanded temperature range for data collection from -150 ¿C to 180 ¿C. The instrument will be located in the NMR Core facility, the only source of analytical NMR available to researchers at Weill Medical College of Cornell University. Relevance: NMR spectrometers are essential for molecular structure determination and chemical identification. The acquisition of a 500 MHz NMR will directly support NIH sponsored research aimed at understanding and combating bacterial infection, malaria, AIDS, cancer, tuberculosis, Alzheimer's, Parkinson's and cardiovascular diseases. The instrument purchased will be employed to identify and characterize proteins and peptides involved in disease processes that might serve as pharmaceutical targets, as well as synthetic molecules that influence bioactivity.

描述（由申请人提供）：在本提案中，要求提供资金以购买500 MHz NMR光谱仪，以支持康奈尔大学威尔医学院的生物医学研究。该仪器将直接支持16个NIH资助的研究赠款，并作为医学院的核心资源。目前，该大学有一台核磁共振光谱仪专门用于蛋白质的核磁共振结构分析。威尔康奈尔大学对合成化合物、天然产物和小肽的分析需求日益增长，用于各种生物学和医学研究。所要求的仪器将大大减轻唯一光谱仪的负担，为生物和合成化学提供分析能力，并支持新建立的化学合成核心设施。NMR光谱仪将针对小分子和肽研究进行优化。NMR将包括一个反向1H/13 C/15 N探针，具有三个射频通道，能够进行三重共振实验。该仪器将具有Weill-Cornell目前不存在的功能，并且在当地不可用。其中包括：1）用于直接检测1H、19 F、31 P、11 B、13 C、23 Na和15 N的宽带探针; 2）用于自动进样和数据采集的多进样器; 3）用于数据采集的扩展温度范围为-150 ℃至180 ℃。该仪器将位于NMR核心设施中，这是康奈尔大学威尔医学院研究人员可用的分析NMR的唯一来源。相关性：核磁共振波谱仪对于分子结构测定和化学鉴定至关重要。收购500 MHz NMR将直接支持NIH赞助的研究，旨在了解和对抗细菌感染，疟疾，艾滋病，癌症，结核病，阿尔茨海默氏症，帕金森氏症和心血管疾病。购买的仪器将用于鉴定和表征可能作为药物靶点的疾病过程中涉及的蛋白质和肽，以及影响生物活性的合成分子。