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Acquisition of a Cold Probe and Console for a 600MHz NMR spectrometer

购买用于 600MHz NMR 波谱仪的冷探头和控制台

基本信息

批准号：
8447822
负责人：
WILLIAM C BRACKEN
金额：
$ 60万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2015-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal requests funds to acquire a console and cold probe for a 600MHz NMR spectrometer to support biomolecular research at Weill Cornell Medical College. The instrument will directly support six NIH funded investigators and serve as a core resource for the medical college. Weill Cornell currently posses a single Varian 600 MHz spectrometer for high resolution heteronuclear protein NMR applications. Current utilization includes drug binding studies, PRE distance measurements, heteronuclear resonance assignments, protein structure determination and protein dynamics characterization. This is the only instrument at the university equipped for triple and quadruple resonance experiments, which is its primary mode of operation. The console and cold probe requested will replace13 year old electronics and provide a state of the art probe to better meet the demand for instrument time. This instrumentation will provide new capabilities including: enhanced signal-to-noise, improved salt tolerance, direct detection of 13C nuclei in addition to improved 1H sensitivity, and state-of-the-art NMR data collection and detection schemes. These features are currently unavailable on our older system. The instrumentation will positively impact basic and translational NIH funded research of relevance to cancer, neural growth/repair, diabetes, cardiovascular disease and amyloid pathogenesis.

描述（由申请人提供）：该提案要求资金为600 MHz NMR光谱仪购买控制台和冷探头，以支持威尔康奈尔医学院的生物分子研究。该仪器将直接支持六名NIH资助的研究人员，并作为医学院的核心资源。Weill Cornell目前正在开发一台Varian 600 MHz光谱仪，用于高分辨率杂合蛋白质NMR应用。目前的应用包括药物结合研究，PRE距离测量，异源共振分配，蛋白质结构测定和蛋白质动力学表征。这是该大学唯一配备三重和四重共振实验的仪器，这是其主要操作模式。所要求的控制台和冷探头将取代13年的旧电子设备，并提供最先进的探头，以更好地满足仪器时间的需求。该仪器将提供新的功能，包括：增强的信噪比，提高耐盐性，除了提高1H灵敏度外，还可以直接检测13 C核，以及最先进的NMR数据收集和检测方案。这些功能目前在我们的旧系统上不可用。该仪器将积极影响NIH资助的与癌症、神经生长/修复、糖尿病、心血管疾病和淀粉样蛋白发病机制相关的基础和转化研究。