RICHMOND AIDS CONSORTIUM 'CPCRA'

说明(改编自申请摘要)：的长期目标 里士满艾滋病联盟(RAC)将获得关于 通过开展治疗试验对艾滋病毒感染的临床管理 在传统上在临床研究和研究中代表性不足的人群中 通常无法获得最先进的医疗保健。这将会实现的 在本提案的整个生命周期中，遵循以下设计 要点：(1)每个人将有一名初级保健医生，精通 管理艾滋病毒，并负责个人的全面医疗 护理；(2)研究护士将在治疗期间实时跟踪患者 病人到诊所探访；及(3)社会工作和药房服务 适用于所有患者。此设计的基础架构包括 弗吉尼亚联邦大学/医学院初级保健提供者网络 弗吉尼亚大学医院(VCH/MCVH)及其附属退伍军人医院， 里士满大都会社区的七名医生，以及增加了一名 与诺福克的东弗吉尼亚医学院有关的新网站。这个 立即可用的患者总数为2828人，另有4000人 出现在集水区。一个中心IRB，一个中心实验室，以及 一家中心药房已全部到位并正常运作。社区咨询 董事会(CAB)正在运作，并通过以下方式为研究议程做出贡献 患者招募以及有关概念和方案的建议。调查人员将 通过招募患者为研究议程做出贡献，以及 参与概念和协议的开发。一个QA计划已经到位， 数据收集和审查的方法、不良事件报告、监管 事务和健全的财政管理和问责。RAC急于启动 IL-2、PIP和FIRST协议，并期望注册或遵循 在任何给定的时间，病房都有200名病人。

DESCRIPTION (adapted from application's abstract): The long-term objective of the Richmond AIDS Consortium (RAC) is to acquire knowledge regarding the clinical management of HIV infection through the conduct of therapeutic trials in populations who are traditionally underrepresented in clinical research and often without access to state-of-the-art health care. This will be achieved throughout the life of this proposal by adhering to the following design points: (1) each individual will have a primary care physician, versed in the management of HIV, and responsible for the individual's comprehensive medical care; (2) research nurses will follow patients in real time during the patients' office visits; and (3) social work and pharmacy services will be available for all patients. The infrastructure for this design consists of a network of primary care providers at Virginia Commonwealth University/Medical College of Virginia Hospital (VCH/MCVH) and its associated Veterans Hospital, seven physicians in the Richmond metropolitan community, and the addition of a new site associated with Eastern Virginia Medical School in Norfolk. The total number of patients immediately available is 2,828 with another 4,000 present in the catchment area. One central IRB, one central laboratory, and one central pharmacy are all in place and functioning. A Community Advisory Board (CAB) is functioning and contributes to the Research Agenda through patient recruitment and advice on concepts and protocols. Investigators will contribute to the Research Agenda through enrolling patients, and participating in concept and protocol development. A QA plan is in place, methods for data collection and review, adverse event reporting, regulatory affairs and sound fiscal management and accountability. RAC is eager to start the IL-2, PIP and FIRST protocols and expects to either enroll or be following 200 patients at the unit at any given time.