RICHMOND AIDS CONSORTIUM 'CPCRA'

里士满艾滋病联盟“CPRA”

• 批准号: 6729928
• 负责人: DANIEL E NIXON
• 金额: $ 94.89万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6729928
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS therapy; antiAIDS agent; chemoprevention; clinical research; clinical trials; community health services; cooperative study; drug screening /evaluation; human subject; human therapy evaluation; longitudinal human study; opportunistic infections; patient oriented research; prognosis; therapy compliance

DESCRIPTION (adapted from application's abstract): The long-term objective of the Richmond AIDS Consortium (RAC) is to acquire knowledge regarding the clinical management of HIV infection through the conduct of therapeutic trials in populations who are traditionally underrepresented in clinical research and often without access to state-of-the-art health care. This will be achieved throughout the life of this proposal by adhering to the following design points: (1) each individual will have a primary care physician, versed in the management of HIV, and responsible for the individual's comprehensive medical care; (2) research nurses will follow patients in real time during the patients' office visits; and (3) social work and pharmacy services will be available for all patients. The infrastructure for this design consists of a network of primary care providers at Virginia Commonwealth University/Medical College of Virginia Hospital (VCH/MCVH) and its associated Veterans Hospital, seven physicians in the Richmond metropolitan community, and the addition of a new site associated with Eastern Virginia Medical School in Norfolk. The total number of patients immediately available is 2,828 with another 4,000 present in the catchment area. One central IRB, one central laboratory, and one central pharmacy are all in place and functioning. A Community Advisory Board (CAB) is functioning and contributes to the Research Agenda through patient recruitment and advice on concepts and protocols. Investigators will contribute to the Research Agenda through enrolling patients, and participating in concept and protocol development. A QA plan is in place, methods for data collection and review, adverse event reporting, regulatory affairs and sound fiscal management and accountability. RAC is eager to start the IL-2, PIP and FIRST protocols and expects to either enroll or be following 200 patients at the unit at any given time.

描述（改编自申请摘要）： 里士满艾滋病联盟（RAC）将获得有关 通过开展治疗试验对艾滋病毒感染进行临床管理 在传统上在临床研究中代表性不足的人群中， 他们往往得不到最先进的医疗服务。 完成这项工作的方法是 在本建议书的整个生命周期内， 要点：（1）每个人都将有一个初级保健医生，精通 管理艾滋病毒，并负责个人的全面医疗 护理;（2）研究护士将在研究期间真实的时间内跟踪患者。 （3）社会工作及药剂服务将会 适用于所有患者。 此设计的基础结构包括 弗吉尼亚联邦大学/医学中心的初级保健提供者网络 弗吉尼亚大学医院（VCH/MCVH）及其相关的退伍军人医院， 七名医生在里士满大都市社区，并增加了一个 新网站与东弗吉尼亚医学院在诺福克。 的 可立即提供服务的病人总数为2，828人，另有4，000人 存在于集水区。 一个中心IRB，一个中心实验室，和 一个中心药房都已到位并在运作。 社区咨询 董事会（CAB）正在运作，并通过以下方式为研究议程做出贡献： 患者招募以及概念和方案方面的建议。 调查人员将 通过招募患者为研究议程做出贡献，以及 参与概念和协议的制定。 质量保证计划已到位， 数据收集和审查方法、不良事件报告、监管 健全的财政管理和问责制。 RAC渴望启动 IL-2、PIP和FIRST方案，并希望注册或遵循 任何时候都有200个病人。