Joint function throughout the life course

整个生命过程中的关节功能

• 批准号: 2890982
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2890982
• 关键词: Joint; function; throughout; life; course

A majority of people (and many domestic pets) experience painful joint disorders such as osteoarthritis as they age. We know that mechanical loading of the joint plays a major role in joint health, yet we still have a limited understanding of how joint loading changes through life as the different tissues of the joint (inluding bone, cartilage, connective tissues and muscle) develop, are maintained and begin to degenerate. In this project using computational modeling (particularly Finite Element Analysis) along with advanced in vivo imaging (computed tomography, lightsheet, confocal and multi photon microscopy) you will study how joints are made, and maintained throughout the whole lifespan of a model organism, the zebrafish. Using transgenic reporter lines you will study how the tissues of the joint come together. Using computational modeling you will test how strain patterns change through life so that we can identify which cells are under high and low strain, and begin to unpick (using transgenic reporters and genetic mutant lines) why cells behave in certain ways in the joint as they repair damage and as they age. The project will suit someone with an interest in genetics, in vivo imaging and computational modeling. You will work with groups who have pioneered use of the techniques that the project will use. The project will give you an interdisciplinary skill set that should benefit you in your further career.

随着年龄的增长，大多数人（以及许多家养宠物）都会经历骨关节炎等疼痛性关节疾病。我们知道关节的机械负荷在关节健康中起着重要作用，但我们对随着关节的不同组织（包括骨、软骨、结缔组织和肌肉）发育、维持和开始退化而在一生中关节负荷如何变化的了解仍然有限。在这个项目中，您将使用计算模型（特别是有限元分析）以及先进的体内成像（计算机断层扫描、光片、共焦和多光子显微镜）来研究关节是如何形成的，以及如何在模型生物斑马鱼的整个生命周期中进行维护。使用转基因报告系，您将研究关节组织如何聚集在一起。使用计算模型，您将测试生命中应变模式如何变化，以便我们能够识别哪些细胞处于高应变和低应变下，并开始揭示（使用转基因报告基因和基因突变系）为什么细胞在修复损伤和衰老时在关节中以某些方式表现。该项目适合对遗传学、体内成像和计算建模感兴趣的人。您将与率先使用该项目将使用的技术的小组合作。该项目将为您提供跨学科技能，这将使您在未来的职业生涯中受益。