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Utilising a systems approach to advance our understanding of immune responses to viral vectors]

利用系统方法来增进我们对病毒载体免疫反应的理解]

基本信息

批准号：
2891798
负责人：
金额：
--
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2891798
关键词：
Utilising systems approach advance our

项目摘要

Viral vectors have been used successfully as vaccines and gene-therapies. Viral vector vaccines had a profound impact on the course of the COVID-19 pandemic, with estimates of over 6.5 million lives saved in 2021 alone due to viral vector-based vaccines. Moreover, viral vector gene therapies have drastically improved both the duration and quality of life of patients with hereditary diseases. This project aims to utilise contemporary bioinformatic and system biology approaches to glean a high-resolution view of immune responses to viral vectors. The immune response to viral vectors is complex and depending on the purpose of therapy the desired immune responses may be highly disparate (i.e., immunostimulatory for vaccines versus immune evasion for gene therapy). Conversely, common challenges are faced in the development of both viral vector vaccines and gene therapies such as anti-vector immunity, packaging capabilities, transduction efficacy, tissue tropism, dosing, and safety. To optimise the use of viral vectors, a better understanding of their interaction with the immune systems is required. Recent technological advances, in the areas of genomics, epigenomics, transcriptomics and proteomics, offer the opportunity to reveal the immunology underlying responses to viral vectors at an unprecedented resolution. These data could revolutionize the way viral vector-based therapies are used

病毒载体已成功用作疫苗和基因疗法。病毒载体疫苗对 COVID-19 大流行的进程产生了深远的影响，据估计，仅 2021 年，基于病毒载体的疫苗就挽救了超过 650 万人的生命。此外，病毒载体基因疗法极大地改善了遗传性疾病患者的生活持续时间和质量。该项目旨在利用当代生物信息学和系统生物学方法来收集对病毒载体的免疫反应的高分辨率视图。对病毒载体的免疫反应是复杂的，并且根据治疗目的，所需的免疫反应可能非常不同（即疫苗的免疫刺激与基因治疗的免疫逃避）。相反，病毒载体疫苗和基因疗法的开发面临着共同的挑战，例如抗载体免疫、包装能力、转导功效、组织向性、剂量和安全性。为了优化病毒载体的使用，需要更好地了解它们与免疫系统的相互作用。基因组学、表观基因组学、转录组学和蛋白质组学领域的最新技术进步提供了以前所未有的分辨率揭示病毒载体反应背后的免疫学的机会。这些数据可能会彻底改变基于病毒载体的疗法的使用方式