Integrated PhD Biomedical Science

核糖体-DNA(RDNA)重复序列是基因组中产生核糖体RNA的基本DNA元件，核糖体RNA是核糖体的组成部分，核糖体的合成在癌症中普遍上调。RDNA中的基因改变与多种癌症有关，然而，到目前为止，对癌症中这些改变的研究在技术上一直具有挑战性。利用最先进的成像、基因组学和蛋白质组学方法，本研究项目旨在阐明癌症中rDNA失调的复杂动力学。通过表征rDNA在不同癌细胞系中的排列和活性，以及探索rDNA区域内重排的功能后果，我们旨在揭示rDNA改变对恶性肿瘤的潜在机制和功能贡献。

Ribosomal-DNA (rDNA) repeats are essential DNA elements within our genome that produce ribosomal RNA, the building blocks of ribosomes, the sysnthesis of which is universally upregulated in cancer. Genetic alterations in rDNA have been implicated in various cancers, however the study of these alterations in cancer has been technically challenging up to now. Using state-of-art imaging, genomics, and proteomics approaches, this research project aims to elucidate the intricate dynamics of rDNA dysregulation in cancer. By characterizing the arrangement and activity of rDNAs in diverse cancer cell lines, and exploring the functional consequences of rearrangements within rDNA regions, we aim to unravel the underlying mechanisms and functional contributions of rDNA alterations to malignancy.