Integrated PhD Biomedical Science

生物医学综合博士

• 批准号: 2892013
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2892013
• 关键词: Integrated; PhD; Biomedical; Science

Ribosomal-DNA (rDNA) repeats are essential DNA elements within our genome that produce ribosomal RNA, the building blocks of ribosomes, the sysnthesis of which is universally upregulated in cancer. Genetic alterations in rDNA have been implicated in various cancers, however the study of these alterations in cancer has been technically challenging up to now. Using state-of-art imaging, genomics, and proteomics approaches, this research project aims to elucidate the intricate dynamics of rDNA dysregulation in cancer. By characterizing the arrangement and activity of rDNAs in diverse cancer cell lines, and exploring the functional consequences of rearrangements within rDNA regions, we aim to unravel the underlying mechanisms and functional contributions of rDNA alterations to malignancy.

核糖体-DNA （rDNA）重复序列是我们基因组中产生核糖体RNA的基本DNA元素，核糖体RNA是核糖体的组成部分，其合成在癌症中普遍上调。rDNA的遗传改变与多种癌症有关，然而，到目前为止，对这些改变在癌症中的研究在技术上一直具有挑战性。利用最先进的成像、基因组学和蛋白质组学方法，本研究项目旨在阐明癌症中rDNA失调的复杂动力学。通过表征不同癌细胞系中rDNA的排列和活性，并探索rDNA区域重排的功能后果，我们旨在揭示rDNA改变对恶性肿瘤的潜在机制和功能贡献。