Investigating and targeting EGFR heterogeneity in glioblastoma

研究和靶向胶质母细胞瘤中 EGFR 异质性

• 批准号: 2892067
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2892067
• 关键词: Investigating; targeting; EGFR; heterogeneity; glioblastoma

Glioblastoma is the most common adult brain tumour, with a dismal overall survival, which is partly due to tumour heterogeneity and treatment-resistance. Epidermal Growth Factor Receptor (EGFR) is commonly altered in glioblastoma and different EGFR mutations can co-occur in a single tumour, and even in a single tumour cell, driving resistance. Despite intense research into EGFR function, insights into the functional impact of EGFR heterogeneity in glioblastoma are hampered by the lack of appropriate models. In this project, we will use the fruit fly Drosophila and mammalian tissue culture to study how EGFR heterogeneity impacts on glioblastoma development and progression.

胶质母细胞瘤是最常见的成人脑肿瘤，总体生存率很低，部分原因是肿瘤的异质性和治疗耐药性。表皮生长因子受体（EGFR）通常在胶质母细胞瘤中发生改变，不同的EGFR突变可以在单个肿瘤中共同发生，甚至在单个肿瘤细胞中共同发生，从而产生耐药性。尽管对EGFR功能进行了深入研究，但由于缺乏适当的模型，对胶质母细胞瘤中EGFR异质性的功能影响的见解受到阻碍。在这个项目中，我们将使用果蝇和哺乳动物组织培养来研究EGFR异质性如何影响胶质母细胞瘤的发展和进展。