权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Longitudinal Lung Function Changes--Aging/Genetics/Risk

纵向肺功能变化——衰老/遗传学/风险

基本信息

批准号：
7266968
负责人：
AUGUSTO A LITONJUA
金额：
$ 36.34万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7266968
关键词：
Address Affect Age Aging Aging-Related Process Asthma Attention Blood Body Weight Changes Candidate Disease Gene Cardiovascular Diseases Characteristics Chromosome Mapping Chronic Chronic Obstructive Airway Disease Chronic Obstructive Asthma Communities Complex Count Data Data Analyses Diabetes Mellitus Diet Disease EPHX1 gene Epidemiology Family GSTP1 gene Gene Order General Population Genes Genetic Genetic Determinism Genetic Programming Genetic Risk Genetic Variation Glutathione S-Transferase IL8RA gene Inflammation Inflammatory Interleukin 8A Receptor Interleukin-10 Interleukins Laboratories Language Lead Life Style Light Link Lung Lung diseases Measurement Measures Mediating Memory Metabolic Microsomal Epoxide Hydrolase Minority Modeling Morbidity - disease rate Organ Outcome Oxidative Stress Participant Pathway interactions Pattern Phenotype Physical activity Proteins Questionnaires Rate Research Design Research Personnel Respiratory physiology Risk Factors Smoke Smoker Smoking Smoking Status Source Sparrows Speed Stimulus Testing Transforming Growth Factors Tumor Necrosis Factor-alpha Tumor Necrosis Factors United States Variant Vital capacity Weight White Blood Cell Count procedure base blood lipid cigarette smoking cigarette smoking cognitive function cohort diet and exercise functional status genetic epidemiology genetic pedigree glutathione S-transferase pi healthy aging heme oxygenase-1 human TNF protein indexing insight mortality programs respiratory response time use

项目摘要

DESCRIPTION (provided by applicant): Low lung function is a central characteristic of chronic obstructive pulmonary disease (COPD), an important cause of morbidity and mortality in the United States. Furthermore, low lung function has been associated with various diseases such as diabetes and cardiovascular disorders, and is associated with all-cause mortality. Although smoking remains the strongest risk factor for low lung function and COPD, only a minority of smokers develop clinically recognized low lung function and COPD. Furthermore, about 6- 10% of the general population have unrecognized low lung function. Thus, a better understanding of the risk factors associated with low lung function is necessary. Since inflammatory markers are seen to be elevated even in healthy aging, we hypothesize that inflammatory mechanisms are common to both aging and lung function decline. In response to this RFA, we intend to perform longitudinal analyses of lung function change, in a cohort that has been followed for about 30 years. We will investigate systemic markers of inflammation for their effect on lung function decline in aging. Because there is great variation in the response to smoking, we also hypothesize that response to smoking and other inflammatory stimuli are modified by genetic variation. We will study genes that participate in these inflammatory pathways (e.g. interleukin[IL]-6, IL-10, IL-2, and tumor necrosis factor[TNF]-alpha) for their effect on rates of lung function decline. The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging.