Limbic & Motor System Interaction in Laryngeal Function

边缘系统

• 批准号: 7250876
• 负责人: DOUGLAS J VAN DAELE
• 金额: $ 19.5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7250876
• 关键词: Affect; Amygdaloid structure; Anterior; Anxiety; Area; Aversive Stimulus; Axon; Behavior; Blepharospasm; Brain; Brain Injuries; Brain Stem; Breathing; Cell Nucleus; Characteristics; Clinical; Condition; Data; Deep Brain Stimulation; Deglutition; Development; Disease; Disinhibition; Dyes; Dysphonia; Dystonia; Facial nerve nucleus; Fluorescent Dyes; Focal Dystonias; Functional Imaging; Functional Magnetic Resonance Imaging; Generations; Goals; Ingestion; Injection of therapeutic agent; Label; Laryngeal muscle structure; Larynx; Limbic System; Maps; Medical; Methods; Monkeys; Motor; Motor Cortex; Motor Neurons; Movement; Muscle; N-Methyl-D-Aspartate Receptors; Nervous system structure; Neurons; Neurotransmitter Receptor; Operative Surgical Procedures; Output; Pathway interactions; Patients; Phase; Play; Primates; Principal Investigator; Process; Production; Rattus; Recovery; Recurrent Laryngeal Nerve; Reflex action; Research; Research Personnel; Respiration; Rodent; Role; Shapes; Spastic Dysphonias; Specificity; Speech; Structure; Suid Herpesvirus 1; Synapses; System; Techniques; Testing; Thyroarytenoid Muscle; Voice Disorders; Work; base; chronotropic; cingulate cortex; concept; cricoarytenoideus; design; gamma-Aminobutyric Acid; insight; nerve supply; novel; nucleus ambiguus; physiologic model; programs; psychologic; receptor; response; species difference; therapeutic target; therapy development; vocal cord

DESCRIPTION (provided by applicant): The long-term goal of this research is to better characterize the role of higher-level nervous system connections to brainstem structures involved in speech and in swallowing. The hypothesis to be tested is that there exists an interaction that plays a role in spasmodic dysphonia between the nucleus ambiguus and two major areas of the limbic system, the anterior cingulate cortex and amygdala. Furthermore, we hypothesize these two areas act differentially upon the nucleus ambiguus: the anterior cingulate system is excitatory and acts upon voluntary behaviors, while the amygdalar system is inhibitory and exerts its effect by modulating brainstem reflexes. To test this hypothesis, we propose the following specific aims: 1) to determine the detailed neuroanatomic connection from the nucleus ambiguus to the amygdala and anterior cingulate cortex; 2) to determine the level at which the interaction occurs; and 3) to determine the neurotransmitter receptors involved in the interaction. Each aim builds upon the other, in that the first aim establishes the connection, the second establishes the organization of the connection, and the third characterizes the effect of the connection on its target. Both the monkey and the rat systems will be studied to exploit evolutionary related species differences in brain and brainstem organization. The significance of this research is that, once characterized, these pathways can be targeted for further study with functional imaging studies, for novel medical and surgical therapies, and for the development of physiologic models. It will promote a better understanding of how speech is acquired and generated at the cortical level, of voice disorders such as spasmodic dysphonia, of the focal dystonias, and of speech recovery after brain injury.

描述（由申请人提供）：本研究的长期目标是更好地描述与语言和吞咽有关的脑干结构的高级神经系统连接的作用。待验证的假设是，在模棱两可核和边缘系统的两个主要区域，前扣带皮层和杏仁核之间存在一种相互作用，在痉挛性发音障碍中起作用。此外，我们假设这两个区域对模棱两可核的作用是不同的：前扣带系统是兴奋性的，作用于自愿行为，而杏仁核系统是抑制性的，通过调节脑干反射来发挥作用。为了验证这一假设，我们提出以下具体目标：1)确定模棱两可核与杏仁核和前扣带皮层之间的详细神经解剖学连接；2)确定相互作用发生的水平；3)确定参与相互作用的神经递质受体。每一个目标都建立在另一个目标之上，因为第一个目标建立联系，第二个目标建立联系的组织，第三个目标描述联系对其目标的影响。猴子和大鼠系统都将被研究，以利用大脑和脑干组织中进化相关的物种差异。这项研究的意义在于，一旦确定了这些通路的特征，这些通路就可以作为进一步研究的目标，用于功能成像研究、新的医学和外科治疗以及生理模型的开发。它将促进更好地理解语言是如何在皮质水平上获得和产生的，痉挛性发音障碍等语音障碍，局灶性张力障碍，以及脑损伤后的语言恢复。