Genetics of DNA Methylation and Its Role in Disease Susecptibility

DNA 甲基化遗传学及其在疾病易感性中的作用

• 批准号: nhmrc : GNT1083656
• 负责人: Dr Allan McRae
• 金额: $ 41.18万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetics-dna-methylation-disease-susecptibility/1345519
• 关键词: Genetics; DNA; Methylation; Its; Role

DNA methylation is a chemical modification to DNA that sits on the interface of an individual's genetics and environment, which is critical for regulating many cellular processes. There is increasing evidence for a major role of variation in DNA methylation in development of disease and it provides a potential therapeutic target. This research will fill fundamental gaps in our knowledge of the genetic and environmental control of differences in levels of DNA methylation in the population.

DNA甲基化是DNA的一种化学修饰，位于个体遗传和环境的界面上，对调节许多细胞过程至关重要。越来越多的证据表明，DNA甲基化变异在疾病的发展中起着重要作用，它提供了一个潜在的治疗靶点。这项研究将填补我们对人群中DNA甲基化水平差异的遗传和环境控制知识的根本空白。