Deep resequencing of Alcohol Dehydrogenases for alcohol use disorders and esophageal cancer.

针对酒精使用障碍和食道癌的酒精脱氢酶深度重测序。

• 批准号: nhmrc : GNT1060663
• 负责人: Dr Allan McRae
• 金额: $ 39.15万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deep-resequencing-alcohol-esophageal-cancer/1344739
• 关键词: Deep; resequencing; Alcohol; Dehydrogenases; alcohol

Excessive alcohol consumption remains a major public health concern in Australia where the burden of mental health disorders is dominated by substance-use disorders. Alcohol dehydrogenases (ADHs) are essential in the breakdown of alcohol in the body and we seek to resequence seven ADH genes with the aim to comprehensively catalogue and identify sequence variants that contribute to risk for consuming excessive quantities of alcohol, alcoholism and esophageal squamous cell carcinoma.

在澳大利亚，过度饮酒仍然是一个主要的公共卫生问题，因为精神健康障碍的负担主要是物质使用障碍。酒精脱氢酶（ADHs）对体内酒精的分解至关重要，我们试图对七个ADH基因进行重排序，目的是全面编目和确定导致过量饮酒、酒精中毒和食管鳞状细胞癌风险的序列变异。