Role of CCK Receptor in Acute Pancreatitis Pathogenesis

CCK受体在急性胰腺炎发病机制中的作用

• 批准号: 7174243
• 负责人: ISAAC SAMUEL
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-15 至 2008-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174243
• 关键词: Role; CCK; Receptor; Acute; Pancreatitis

secretarial support, laboratory space, technical help, start-up funds and 80% protected time have been ensured for the candidate. The collaborative environment at the University of iowa and College of Medicine is particularly conducive towards the advancement of science and the nurturing of new investigators. Dr. Rory Fisher, PhD, Associate Professor, Department of Pharmacology, has extensive knowledge, experience, and expertise in the study of G-protein coupled receptors. His laboratory routinely performs the competitive bindingassays and signal transduction studies described in this protocol. Dr. Fisher is an enthusiastic teacher and will play an important collaborative role in this project. The candidate will receive training in molecular aspects of studies in receptor function and signal transduction in Dr. Fisher's laboratory. Dr. Christie Thomas, MD, Associate Professor of Nephrology, has assisted the candidate develop the ribonuclease protection assay for rat cholecystokinin-A receptor mRNA and will collaborate for future mRNA studies involved inthe project. Dr. David Elliott, MD, PhD, Associate Professor of Gastroenterology, is a member of Dr. Weinstock's laboratory team and will collaborate in investigations involving receptor function and regulation of inflammatory mediators. Clearly, full advantage is being taken of the rich collaborative resources available in the environment to enable the success of this research proposal and the training of the candidate. 5b) Institutional Commitment to Candidate's Research Career Development Dr. Carol Scott-Connor, MD, PhD, Head of the Department of Surgery, recruited the candidate for the principal purpose of building a basic science research laboratory. The candidate has been granted 80% protected time from the date of joining the faculty to pursue basic science research. The candidate was given top priority in terms of the provision of laboratory space, technical assistance, and financial resources required to begin his research immediately. The candidate has been assured of similar and continuing support in the future. The Department of Surgery and the University of Iowa College of Medicine have an unwavering commitment to the scientific training and development of the candidate. Evidence of the institutionalcommitment to the candidate's research career development is further documented in letters from Dr. Carol Scott-Conner, MD, PhD, Professor and Head of the Department of Surgery, and Dr. James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page []

秘书处支助、实验室空间、技术帮助、启动资金和 80%的保护时间已被确保为候选人。 爱荷华州大学和医学院的合作环境特别 有利于科学进步和培养新的研究人员。罗里·费舍尔博士 药理学系副教授，拥有丰富的知识，经验和专业知识， G蛋白偶联受体的研究。他的实验室经常进行竞争性结合试验， 本方案中描述的信号转导研究。费希尔博士是一位热情的教师， 在这个项目中扮演重要的角色。候选人将接受研究的分子方面的培训， 受体功能和信号转导的研究。Christie托马斯博士，医学博士，助理 肾脏病学教授，曾协助候选人开发大鼠核糖核酸酶保护试验 胆囊收缩素A受体mRNA，并将合作为未来的mRNA研究参与该项目。博士 大卫埃利奥特，医学博士，博士，胃肠病学副教授，是博士温斯托克的实验室成员 团队，并将在涉及受体功能和炎症介质调节的研究中合作。 显然，正在充分利用环境中丰富的协作资源， 该研究计划的成功和候选人的培训。 5 b）对候选人研究职业发展的机构承诺 博士卡罗尔·斯科特-康纳，医学博士，博士，外科系主任，招募了校长候选人 建设基础科学研究实验室的目的。候选人已获得80%的保护时间 从加入学院之日起从事基础科学研究。这位候选人被给予最优先考虑。 提供实验室空间、技术援助和开始其研究所需的财政资源的条件 立即研究。候选人已得到保证，今后将继续得到类似的支持。的 外科系和爱荷华州大学医学院坚定不移地致力于 科学培养和发展候选人。机构承诺的证据 候选人的研究职业发展进一步记录在卡罗尔斯科特-康纳博士，医学博士， 博士、教授兼外科系主任，以及James W.博士。Maher，医学博士，主任， 胃肠道外科，爱荷华州大学医学院，爱荷华州市。 [] PHS 398/2590（修订版05/01）第__26页续格式第[]页

项目成果

Cholinergic receptor induction and JNK activation in acute pancreatitis.

急性胰腺炎中胆碱能受体诱导和 JNK 激活。

• DOI: 10.1016/j.amjsurg.2003.07.016
• 发表时间: 2003
• 期刊: American journal of surgery
• 影响因子: 3
• 作者: Samuel,Isaac;Zaheer,Smita;Fisher,RoryA;Zaheer,Asgar
• 通讯作者: Zaheer,Asgar

Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion.

肠内胆胰液排除引起急性胰腺炎恶化的机制。

• DOI: 10.1159/000080527
• 发表时间: 2004
• 期刊: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
• 作者: Samuel,Isaac;Toriumi,Yasuo;Zaheer,Asgar;Joehl,RaymondJ
• 通讯作者: Joehl,RaymondJ

Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis.

胆胰液排除可增加结扎诱发的急性胰腺炎中胆碱能 M3 和 CCK-A 受体的表达以及白细胞介素 6 的产生。

• DOI: 10.1016/j.amjsurg.2004.07.008
• 发表时间: 2004
• 期刊: American journal of surgery.
• 作者: Samuel,Isaac;Zaheer,Asgar;Zaheer,Smita;Fisher,RoryA
• 通讯作者: Fisher,RoryA

Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction.

• DOI: 10.1016/j.amjsurg.2005.07.010
• 发表时间: 2005-11
• 期刊: American journal of surgery
• 影响因子: 3
• 作者: I. Samuel;Ashok K. Chaudhary;R. Fisher;R. Joehl