Mononuclear phagocyte activi in cochlea acoustic trauma

耳蜗声损伤中的单核吞噬细胞活性

• 批准号: 7171581
• 负责人: Keiko Hirose
• 金额: $ 16.13万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-05 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171581
• 关键词: Acoustic Trauma; Acoustics; Address; Appearance; Bromodeoxyuridine; CD45 Antigens; Caring; Cell Count; Cell Proliferation; Cells; Chairperson; Chemotactic Factors; Classification; Clinic; Cochlea; Communication impairment; Communities; Development; Disease; Doctor of Medicine; Ear; Electronic Mail; Electrons; Environment; Epithelium; Exhibits; Exposure to; Fever; Foundations; Genetic Transcription; Goals; Grant; Histologic; Immunohistochemistry; In Situ; Individual; Inflammation; Injury; Institution; Interleukin-1; Interleukin-6; Investigation; K-Series Research Career Programs; Knock-out; Knockout Mice; Label; Labyrinth; Leukocytes; Ligands; Light; Location; Macrophage Activation; Maps; Marshal; Membrane; Mentors; Messenger RNA; Microglia; Microscopic; Mission; Monocyte Chemoattractant Protein-1; Mononuclear; Mus; Myelogenous; Myeloid Cells; Natural regeneration; Neuraxis; Neurodegenerative Disorders; Neuroglia; Neurosciences; Noise; Normal Cell; Numbers; Ohio; Otolaryngology; Outcome; PTPRC gene; Pathogenesis; Pattern; Peripheral; Peripheral Nervous System; Phagocytes; Phagocytosis; Phase; Physicians; Physiological; Polymerase Chain Reaction; Population; Principal Investigator; Process; Production; Program Research Project Grants; Proliferating; Proteins; Recovery; Recruitment Activity; Reporting; Research Institute; Research Personnel; Reverse Transcription; Role; Scientist; Sensory; Staining method; Stains; Swelling; TNF gene; Telefacsimile; Testing; Time; Tissues; Vascular Permeabilities; Vascular blood supply; Work; career; cell injury; cell type; chemokine receptor; cytokine; health care quality; macrophage; medical schools; migration; monocyte; neuroimmunology; professor; programs; receptor; repaired; response

Marshall Strome, M.D., M.S., F.A.C.S. Chairman and Professor of Otolaryngology Department of Otolaryngology and Communicative Disorders / A71 Office: 216/444-6686 Fax: [phone] E-mail: stromem@ccf org Environmental and institutional commitment to the candidate Description of Institutional Environment The Cleveland Clinic Foundation is a institution dedicated to providing the best care for the sick and to promote investigation of illness. The Lerner Research Institute was developed in order to expand our basic understandings of the mechanisms of disease processes and to recruit and retain individuals who will make a significant impact on the quality of health care in the years to come. Promoting the career development of physician researchers is therefore a critical part of the mission of this institution. The Department of Neurosciences at the Lerner Research Institute (LRI) is widely recognized for its expertise in the field of neuroimmunology and pathogenesis of neurodegenerative diseases. Dr. Bruce Trapp is the chairman of the Department of Neurosciences and has mentored previous physician-scientists who have obtained K award grants at the Cleveland Clinic Foundation. His expertise in the field of axonal and glial cell degeneration and inflammation in the peripheral and central nervous system is recognized throughout the neuroscience community internationally and is extensively supported by three R01 grants, a program project grant and numerous private foundation grants. Dr. Trapp has demonstrated his ability to mentor successful physician scientists, both at the Cleveland Clinic Foundation and previously at Johns Hopkins School of Medicine, and he is ideally suited to providing guidance and support as well 26 950¿) Euclid Avenue, Cleveland, Ohio 44195

马歇尔斯特罗姆，医学博士，医学硕士，联邦航空公司 耳鼻喉科主席及教授 部 的 耳鼻 沟通障碍/ A71 办事处： 216/444-6686 传真：216/445-9409 电邮地址： Strophe @ccf org 对候选人的环境和体制承诺 描述 体制 环境 The Cleveland Clinic Foundation 是一个致力于提供最好的 照顾病人和促进疾病调查。 Lerner研究 研究所的发展是为了扩大我们的基本理解 的 疾病过程的机制，并招募和留住个人谁将 对今后几年的保健质量产生重大影响。 因此，促进医生研究人员的职业发展是一个关键 这是本机构使命的一部分。 部 神经科学 Lerner研究所（LRI） 因其在神经免疫学领域的专业知识而闻名 及发病机制 神经变性 疾病 布鲁斯特拉普博士是系主任 神经科学和指导以前的医生，科学家谁有 在克利夫兰诊所基金会获得K赠款。 他的专长是 轴突和胶质细胞变性区 以及外周炎症， 中枢神经系统在整个神经科学界都是公认的 国际 并得到三个R 01赠款的广泛支持， 项目赠款和许多私人基金会赠款。特拉普医生 证明了他有能力指导成功的医生科学家，无论是在 克利夫兰临床基金会和以前在约翰霍普金斯医学院 医学，他也非常适合提供指导和支持 26 950欧几里得大道，克利夫兰，俄亥俄州44195