Exploring the decline of human skin barrier function with ageing, and the impact of ethnicity and UVR exposure

探索人类皮肤屏障功能随衰老而下降，以及种族和紫外线照射的影响

• 批准号: 2894496
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2894496
• 关键词: Exploring; decline; human; skin; barrier

Human skin provides a crucial physical barrier to protect the body against environmental insults, notably ultraviolet radiation (UVR) in sunlight. The skin also has several physiological functions including immune surveillance and the control of thermoregulation and water loss. The epidermis of human skin has a key role in preventing excessive loss of water and solutes from the body. Epidermal barrier function is maintained by tight junction complexes in the stratum granulosum, and components of the hydrophobic, lipid rich stratum corneum. Disruption of barrier function is associated with xerosis and more severe, inflammatory skin conditions such as atopic dermatitis and psoriasis. Thus, maintaining a functional epidermal barrier is vital for optimum skin function and environmental protection.The function of skin declines with age, including barrier function, and is influenced by acute and chronic UVR exposure but the impact of ethnicity on these is unknown. Skin from individuals of different geographical ancestry differs not only in pigmentation, but in morphological features such as epidermal thickness and dermal-epidermal junction convolution, and in the composition of the dermal matrix. It is therefore hypothesised that epidermal barrier function may also differ. The aim of this project is to examine how components and function of the epidermal barrier change with ageing, including the impact of chronic and acute UVR exposure, and how this may differ between individuals of different ethnicity. Using a range of laboratory techniques and in vivo assessments, this research will explore the quantity and distribution of key components of the epidermal barrier in human skin. Additionally, the ability of topical sunscreen to protect against changes in the epidermal barrier following acute UVR exposure will be examined.Study findings will make a significant contribution to our understanding of skin biology and epidermal barrier function and may have implications for public health messaging on sunlight exposure and photoprotection. Moreover, it will inform development of skin care products and therapies for the protection and restoration of the skin barrier with respect to ageing and sunlight exposure that will meet the needs of our diverse population. Thus, this project brings together two of the strategic topic areas for Boots/No7 - Skincare for all life stages and Skincare for all ethnicities.

人体皮肤提供了一个重要的物理屏障，以保护身体免受环境的伤害，特别是阳光中的紫外线辐射（UVR）。皮肤还具有几种生理功能，包括免疫监视和温度调节和水分流失的控制。人体皮肤的表皮在防止身体水分和溶质过度流失方面起着关键作用。表皮屏障功能由颗粒层中的紧密连接复合物和疏水的富含脂质的角质层的组分维持。屏障功能的破坏与干燥症和更严重的炎性皮肤病如特应性皮炎和银屑病有关。因此，维持功能性表皮屏障对于最佳皮肤功能和环境保护至关重要。皮肤的功能随着年龄的增长而下降，包括屏障功能，并受到急性和慢性UVR暴露的影响，但种族对这些的影响尚不清楚。来自不同地理祖先的个体的皮肤不仅在色素沉着方面不同，而且在形态特征（例如表皮厚度和真皮-表皮接合处褶曲）以及真皮基质的组成方面也不同。因此，假设表皮屏障功能也可能不同。该项目的目的是研究表皮屏障的成分和功能如何随着年龄的增长而变化，包括慢性和急性UVR暴露的影响，以及不同种族的个体之间的差异。本研究将利用一系列实验室技术和体内评估，探索人类皮肤表皮屏障关键成分的数量和分布。此外，局部防晒霜的能力，以防止在急性紫外线照射后的表皮屏障的变化将examined.Study的发现将作出重大贡献，我们的皮肤生物学和表皮屏障功能的理解，并可能对阳光照射和光防护的公共卫生信息的影响。此外，它还将为开发护肤产品和治疗方法提供信息，以保护和恢复皮肤屏障，防止老化和阳光照射，满足我们多样化人口的需求。因此，该项目汇集了Boots/No 7的两个战略主题领域-所有生命阶段的护肤品和所有种族的护肤品。