Exploring the decline of human skin barrier function with ageing, and the impact of ethnicity and UVR exposure

探索人类皮肤屏障功能随衰老而下降，以及种族和紫外线照射的影响

• 批准号: 2894496
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2894496
• 关键词: Exploring; decline; human; skin; barrier

Human skin provides a crucial physical barrier to protect the body against environmental insults, notably ultraviolet radiation (UVR) in sunlight. The skin also has several physiological functions including immune surveillance and the control of thermoregulation and water loss. The epidermis of human skin has a key role in preventing excessive loss of water and solutes from the body. Epidermal barrier function is maintained by tight junction complexes in the stratum granulosum, and components of the hydrophobic, lipid rich stratum corneum. Disruption of barrier function is associated with xerosis and more severe, inflammatory skin conditions such as atopic dermatitis and psoriasis. Thus, maintaining a functional epidermal barrier is vital for optimum skin function and environmental protection.The function of skin declines with age, including barrier function, and is influenced by acute and chronic UVR exposure but the impact of ethnicity on these is unknown. Skin from individuals of different geographical ancestry differs not only in pigmentation, but in morphological features such as epidermal thickness and dermal-epidermal junction convolution, and in the composition of the dermal matrix. It is therefore hypothesised that epidermal barrier function may also differ. The aim of this project is to examine how components and function of the epidermal barrier change with ageing, including the impact of chronic and acute UVR exposure, and how this may differ between individuals of different ethnicity. Using a range of laboratory techniques and in vivo assessments, this research will explore the quantity and distribution of key components of the epidermal barrier in human skin. Additionally, the ability of topical sunscreen to protect against changes in the epidermal barrier following acute UVR exposure will be examined.Study findings will make a significant contribution to our understanding of skin biology and epidermal barrier function and may have implications for public health messaging on sunlight exposure and photoprotection. Moreover, it will inform development of skin care products and therapies for the protection and restoration of the skin barrier with respect to ageing and sunlight exposure that will meet the needs of our diverse population. Thus, this project brings together two of the strategic topic areas for Boots/No7 - Skincare for all life stages and Skincare for all ethnicities.

人体皮肤提供了至关重要的物理障碍，可保护人体免受环境侮辱，尤其是阳光下的紫外线辐射（UVR）。皮肤还具有多种生理功能，包括免疫监测以及控制体温调节和水分流失。人皮肤的表皮在防止体内过度流失和溶质中具有关键作用。表皮屏障功能通过颗粒颗粒中的紧密连接络合物和疏水性富含脂质富含脂质的角层的成分保持。屏障功能的破坏与疾病和更严重的炎症性皮肤状况有关，例如特应性皮炎和牛皮癣。因此，保持功能表皮屏障对于最佳皮肤功能和环境保护至关重要。皮肤随着年龄的增长（包括屏障功能）的下降，受急性和慢性UVR暴露的影响，但族裔对这些影响的影响尚不清楚。来自不同地理祖先的个体的皮肤不仅在色素沉着方面有所不同，而且在形态学特征（例如表皮厚度和皮肤 - 表皮连接卷积）以及真皮基质的组成方面有所不同。因此，假设表皮屏障功能也可能有所不同。该项目的目的是检查表皮屏障随着衰老的变化的组成部分和功能，包括慢性和急性UVR暴露的影响，以及不同种族个人之间的不同之处。使用一系列实验室技术和体内评估，这项研究将探讨人皮肤皮肤表皮屏障的关键组成部分的数量和分布。此外，将检查局部防晒霜防止急性UVR暴露后表皮屏障变化的能力。研究结果将为我们对我们对皮肤生物学和表皮屏障功能的理解做出重大贡献，并可能对公共卫生信息对太阳暴露和光保护有意义。此外，它将为皮肤护理产品和疗法开发，以保护和恢复皮肤屏障，以满足我们多样化人群的需求，以保护和恢复皮肤屏障。因此，该项目汇集了靴子/No7的两个战略主题领域 - 所有生活阶段的护肤以及所有种族的护肤。