Evaluation of a Computer-Based System using Cell Phones for HIV people in Peru

对秘鲁艾滋病毒感染者使用手机的计算机系统的评估

基本信息

批准号：
7291149
负责人：
Walter Humberto Curioso
金额：
$ 5.08万
依托单位：
UNIVERSIDAD PERUANA CAYETANO HEREDIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7291149
关键词：
18 year old AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Adherence Adult Anti-Retroviral Agents Appointment Behavior Behavioral Blood CD4 Lymphocyte Count Caring Cellular Phone Client satisfaction Clinic Computers Consent Counseling Disease Effectiveness of Interventions End Point Epidemic Evaluation Focus Groups Guidelines HIV HIV Seropositivity HIV-1 Health Health behavior Health care facility Hepatitis B Hepatitis C Individual Infection Information Technology Internet Intervention Interview Life Measurement Measures Modeling Monitor Motivation Outcome Participant Patient Self-Report Patients Peru Pharmaceutical Preparations Policies Population Prevention intervention Public Health Public Health Informatics Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Recruitment Activity Reporting Research Research Personnel Resistance Resistance development Resources Risk Risk Behaviors Risk Reduction Risk Reduction Behavior Sampling Schedule Secondary Prevention Sex Behavior Sexually Transmitted Diseases Standards of Weights and Measures Surveys System Telephone Testing Text Time Training Unsafe Sex Upper arm Viral Load result Visit Voice Vulnerable Populations Work antiretroviral therapy base follow-up innovation interest medication compliance programs response safer sex skills success tool transmission process usability user centered design

项目摘要

DESCRIPTION (provided by applicant): We propose to develop and evaluate a computer-based intervention using cell phones to enhance adherence to antiretroviral treatment (ART) and support of HIV transmission risk-reduction among adult HIV- positive patients in Peru. Adherence to ART is critical for treatment success at the individual level and to avoid the onset of resistant strains of HIV. In Peru, where ART has recently been introduced, adherence to HIV treatment has not yet beenjaddressed properly. Innovative approaches using information technologies such as cell phones are needed to increase adherence to ART for people with HIV/AIDS. The specific aims of the study are to: 1) Conduct formative research to assess culturally-specific behavioral messages to be included in the computer-based system; 2) Develop and test an interactive computer-based system using cell phones to enhance adherence to ART and to deliver HIV transmission risk reduction messages; 3) Evaluate the impact of the system on antiretroviral adherence and sexual risk behaviors. To achieve these aims, we will conduct a randomized controlled trial of a 12-month intervention, comparing [1] standard-of- care (n=50) with [2] standard-of-care plus cell phone-based system (n=50) among patients receiving ART at Via Libre, a non-governmental organization established to help people with HIV. We will recruit 100 adults over 18 years old who are currently on ARTs and give consent. The patients will be recruited during a one- year study period and will be randomly assigned to receive either a cell phone-based system or the standard-of-care. Outcomes between the two groups will be monitored using monthly surveys (by phone or the Internet) to determine effects of the intervention on ART adherence and sexual risk behaviors. Self- reported medication adherence and adherence to clinic appointments; and self-reported HIV transmission risk behaviors will be the primary endpoints of interest; impact on HIV-1 viral load and CD4 count also will be assessed. The intervention group will receive: 1) Tailored reminders via their cell phones to take their ART and attend scheduled HIV clinic appointments; and 2) Tailored HIV transmission risk reduction messages via their cell phones. This pilot randomized-controlled trial will define the need and direction for larger evaluations of this cell phone-based system to assess impact on ART adherence and sexual behaviors of vulnerable populations living with HIV in resource-poor settings.

描述（由申请人提供）：我们建议使用手机开发和评估基于计算机的干预措施，以增强对秘鲁成人HIV-HIV-阳性患者的抗逆转录病毒治疗（ART）的依从性和支持。遵守艺术对于在个体水平的治疗成功和避免艾滋病毒抗性菌株的发作至关重要。在最近引入ART的秘鲁，对艾滋病毒治疗的依从性尚未得到适当的态度。需要使用信息技术（例如手机）的创新方法来增加对艾滋病毒/艾滋病患者的艺术的依从性。该研究的具体目的是：1）进行形成性研究以评估要包含在基于计算机的系统中的文化特定行为信息； 2）使用手机开发和测试基于计算机的系统，以增强对艺术的依从性并传递艾滋病毒传播风险降低消息； 3）评估系统对抗逆转录病毒依从性和性风险行为的影响。为了实现这些目标，我们将对12个月的干预措施进行随机对照试验，将[1]的标准（n = 50）与[2]护理标准加上手机的基于手机的系统（n = 50）进行比较，该系统是在Via Libre（一个非政府组织）接受ART的患者中，该组织是一个旨在帮助患者的非政府组织。我们将招募18岁以上的100名成年人，他们目前正在艺术并同意。将在一年的研究期间招募患者，并将随机分配以接收基于手机的系统或护理标准。两组之间的结果将通过每月调查（通过电话或互联网）进行监控，以确定干预对艺术依从性和性风险行为的影响。自我报告的药物依从性和遵守诊所任命；自我报告的艾滋病毒传播风险行为将是感兴趣的主要终点；还将评估对HIV-1病毒载荷和CD4计数的影响。干预小组将收到：1）通过手机量身定制的提醒，以采用艺术品并参加预定的艾滋病毒诊所约会； 2）通过手机量身定制的HIV传播风险降低消息。这项试验随机控制试验将定义对基于手机的系统进行更大评估的需求和指导，以评估对资源贫乏环境中患有艾滋病毒的脆弱人群的艺术依从性和性行为的影响。