Validation of the NINDS VCI Neuropsychology Protocols

NINDS VCI 神经心理学协议的验证

• 批准号: 7187273
• 负责人: DAVID L NYENHUIS
• 金额: $ 46.49万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7187273
• 关键词: Accounting; Anisotropy; Area; Atrophic; Behavior; Blood Vessels; Brain; Cell Nucleus; Cerebrovascular Disorders; Cerebrum; Chicago; Clinical Trials; Cognitive; Collaborations; Communication; Communities; Condition; Consensus; Data; Dementia; Demographic Accounting; Demographic Factors; Depth; Development; Diagnostic; Diffusion; District of Columbia; Educational workshop; Environment; Epidemiology; Fostering; Genetic; Health Sciences; Illinois; Image; Impaired cognition; Infarction; Ischemic Stroke; Language; Lead; Least-Squares Analysis; Left; Length; Lesion; Location; MRI Scans; Magnetic Resonance Imaging; Manuals; Medical center; Neuropsychological Tests; Neuropsychology; Numbers; Pathology; Patients; Prevalence; Protocols documentation; Psychometrics; Rate; Recruitment Activity; Relative (related person); Research; Research Personnel; Sampling; Score; Sensitivity and Specificity; Site; Standards of Weights and Measures; Stroke; System; Techniques; Testing; Thalamic structure; Time; Universities; Validation; Validity and Reliability; Vascular Dementia; Woman; Work; base; cerebral atrophy; college; improved; indexing; interest; lexical retrieval; neuroimaging; neuropsychological; post stroke; programs; research study; size; white matter

DESCRIPTION (provided by applicant): Cognitive impairment and dementia are common after stroke. However, the criteria with which to describe and categorize stroke patients with vascular cognitive impairment (VCI) are not clear. Previous diagnostic systems have relied upon consensus criteria for conditions such as vascular dementia, but this has led to inconsistencies in the prevalence rate of the condition and the sensitivity and specificity of the criteria, depending upon which diagnostic system is used. Instead of consensus criteria, there is now a call for data- driven diagnostic systems. In April 2005, NINDS and the Canadian Stroke Network co-sponsored a Harmonization Workshop in Washington DC to foster multi-center collaboration and communication in the VCI community by developing standard protocols in the areas of neuropsychology, neuroimaging, epidemiology, pathology, and experimental research. It is hoped that use of these standard protocols will lead to the multi-site, collaborative study of VCI that is necessary to establish diagnostic criteria, examine underlying mechanisms, such as genetic factors, and promote treatment research. As part of the workshop, the Neuropsychology Working Group established three neuropsychology protocols, defined by the length of time necessary to complete them: a 60 Minute Protocol, a 30 Minute Protocol and a Five Minute Protocol. The aim of this project is to test the reliability and validity of these protocols in a multi-center sample of 100 ischemic stroke patients and 100 demographically matched controls. An integral part of the project is to assess the concurrent validity of the neuropsychology test protocols by examining their relationship to known neuroimaging factors, such as the size and location of stroke lesions and subcortical hyperintensities and the extent of cerebral atrophic changes. In addition, the project will explore relationships between the neuropsychology test protocols and both thalamic volumes and diffusion tensor indices, such as fractional anisotropy. Reliable and valid VCI neuropsychology test protocols are a necessary first step to improved diagnostic criteria and a better understanding of both the mechanisms of VCI and the development of new treatment options.

描述（由申请人提供）：中风后常见认知障碍和痴呆。然而，血管性认知障碍（VCI）卒中患者的描述和分类标准尚不清楚。以前的诊断系统依赖于血管性痴呆等疾病的共识标准，但这导致了疾病的患病率以及标准的敏感性和特异性不一致，这取决于使用哪种诊断系统。取代共识标准的是，现在需要的是数据驱动的诊断系统。2005年4月，NINDS和加拿大卒中网络在华盛顿共同主办了一个协调研讨会，通过制定神经心理学、神经影像学、流行病学、病理学和实验研究领域的标准方案，促进VCI社区的多中心合作和交流。希望这些标准方案的使用将导致VCI的多地点协作研究，这对于建立诊断标准、检查潜在机制（如遗传因素）和促进治疗研究是必要的。作为研讨会的一部分，神经心理学工作组建立了三个神经心理学协议，根据完成它们所需的时间长度来定义：60分钟协议，30分钟协议和5分钟协议。本项目的目的是在100名缺血性卒中患者和100名人口统计学匹配的对照者的多中心样本中测试这些方案的可靠性和有效性。该项目的一个组成部分是通过检查它们与已知神经成像因素的关系来评估神经心理学测试协议的并行有效性，这些因素包括中风病变的大小和位置以及皮质下高信号和大脑萎缩变化的程度。此外，该项目将探索神经心理学测试协议与丘脑体积和弥散张量指数（如分数各向异性）之间的关系。可靠有效的VCI神经心理学测试方案是改善诊断标准和更好地理解VCI机制以及开发新治疗方案的必要第一步。