Genetics of HNPCC

遗传性非息肉病性结直肠癌(HNPCC)是一种高风险的终生癌症，尤其是结直肠癌和子宫内膜癌。通过表征患者队列中的疾病表现，澳大利亚背景下的HNPCC将得到更好的定义。这项建议的目的是进行基因调查，以便通过识别与疾病发展相关的基因来完成更全面的个性化患者风险评估。

Hereditary Non-Polyposis Colorectal Cancer (HNPCC) confers a high lifetime risk of developing cancer, especially colorectal and endometrial cancer. By characterising disease presentation in the patient cohort, HNPCC in an Australian context will be better defined. The aim of this proposal is to undertake a genetic investigation such that a more comprehensive personalised patient risk-assessment can be completed by identifying genes related to disease development.