The evolution of nerves: understanding the roots of neurodegeneration

神经的进化：了解神经退行性变的根源

• 批准号: 2894949
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2894949
• 关键词: evolution; nerves; understanding; roots; neurodegeneration

"Axons are slender extensions of neurons which can be meter-long and form the biological cables that run through our nerves to hardwire the nervous system. In humans, axons must survive for up to a century; we lose ~40% of axons towards high age and many more in neurodegeneration, but the causes are poorly understood. To understand axon maintenance and pathologies, we are focussing on the bundles of microtubules (MTs) that run all along axons - be it in a tiny fly or in a human [Ref1]. These bundles determine axon structure and form the highways for life-sustaining axonal transport. Accordingly, MT bundle decay causes axon degeneration. But the mechanisms that maintain these bundles (and might fail in pathology!) are little understood "

轴突是神经元的细长延伸，可以长米，并形成贯穿我们神经的生物电缆，从而使神经系统延伸。沿着轴突奔跑 - 在人类中或人类中，这些束结构确定了轴突的结构，并形成了持久的轴突运输。