Pharmacologic MRI of Smoked Tobacco: Effects of Abstinence and Dependence

描述（由申请人提供）：简介：本申请描述了根据K01指导研究科学家发展机制进行三年指导培训的建议。候选人在非人灵长类动物药物滥用研究的背景下具有一定的行为药理学经验，并建议过渡到与人类研究参与者一起工作。候选人还具有PET神经成像的相关经验，并建议过渡到磁共振（MR）成像。要求支持一个相对较短的三年培训计划，包括课程，会议和积极参与研究的组合。人类行为药理学的导师，斯科特·E. Lukas和MR神经成像的共同导师佩里·伦肖博士和布莱斯·弗雷德里克博士将密切参与候选人的培训和拟议研究的执行。拟议的培训计划将使该申请人能够在相关领域建立坚实的基础，并以一种促进她发展成为行为药理学和神经影像学独立研究人员的方式完善她的专业知识，并使她能够成功回答有关药物滥用和公共卫生的重要科学问题。机构和培训计划：姆克林医院神经影像中心非常适合本申请中提出的培训类型。它与行为精神药理学研究实验室位于同一栋大楼内。这促进了涉及行为药理学组成部分和神经成像组成部分的项目的合作。神经影像中心配备了高素质的教师，并致力于职业发展，特别是年轻的研究人员。拟议的培训计划是全面的，并提供教学和实践的组成部分，这将有助于这位候选人实现她的目标，成为行为药理学和MR神经成像领域的专家。该研究项目，题为吸烟的药理学MRI：禁欲和依赖的影响，将回答有关吸烟对BOLD信号的急性影响的几个重要和及时的问题，这是大脑激活的相关因素，并为候选人提供学习独立和富有成效的研究生涯所需的基本知识和研究技能的机会。

DESCRIPTION (provided by applicant): Introduction: This application describes a proposal for three years of mentored training under the K01 Mentored Research Scientist Development mechanism. The candidate has some experience with behavioral pharmacology in the context of drug abuse research with nonhuman primates, and proposes to make a transition to working with human research participants. The candidate also has relevant experience with PET neuroimaging, and proposes to make a transition to magnetic resonance (MR) imaging. Support is requested for a relatively short three-year training program that consists of a combination of coursework, meetings, and active participation in research. A mentor in human behavioral pharmacology, Dr. Scott E. Lukas and co mentors in MR neuroimaging, Drs. Perry Renshaw and Blaise Frederick will be closely involved in the candidate's training and the execution of the research proposed. The proposed training program will enable this applicant to build on strong foundations in related areas and refine her expertise in a way that will facilitate her development into an independent researcher in behavioral pharmacology and neuroimaging, and enable her to successfully answer important scientific questions relating to drug abuse and public health. Institution and Training Program: The McLean Hospital Neuroimaging Center is very well suited for the type of training proposed in this application. It is conveniently located in the same building as the Behavioral Psychopharmacology Research Laboratory. This promotes collaboration on projects involving both a behavioral pharmacology component and a neuroimaging component. The Neuroimaging Center is staffed with highly qualified faculty and is committed to career development, especially for young investigators. The proposed training program is comprehensive and offers both didactic and practical components that will help this candidate achieve her goal of becoming expert in the fields of behavioral pharmacology and MR neuromaging. The research project, entitled Pharmacological MRI of tobacco smoking: Effects of abstinence and dependence, will answer several important and timely questions about the acute effects of tobacco smoking on BOLD signal, a correlate of brain activation, as well as provide opportunities for the candidate to learn the essential knowledge and research skills necessary for independence and a productive research career.