Understanding Prescription Decisions in Schizophrenia

了解精神分裂症的处方决定

基本信息

  • 批准号:
    7211460
  • 负责人:
  • 金额:
    $ 14.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2009-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by candidate): This revised application outlines an integrated training and research program for a NIMH K01 Mentored Research Scientist Development Award. My long-term career goal is to develop a program of research focused on medication effectiveness in individuals with serious mental illnesses (SMI) that includes investigating the process and outcomes of medication prescription in typical clinical practice settings, and applying this knowledge to the design of interventions to improve medication prescription decisions. My immediate career goal is to understand the prescription of complex, multi-drug regimens ('polypharmacy') in schizophrenia, focusing specifically on combination antipsychotic regimens in this application. Both clinician-related ('supply-side') and patient and family-related ('demand-side') factors, which are equally important and influential forces affecting medication management decisions will be considered. To achieve these goals, I will complete didactic coursework and mentored training activities concurrently with research projects that focus on prescription decision-making, anti-psychotic polypharmacy, and survey methods, as well as the development of interventions to improve prescription decisions in schizophrenia. These activities will be conducted under the guidance of several faculty members from across the country with expertise in mental health services research, psychopharmacology, and both cognitive and clinical psychology. A research plan of four projects is proposed. The first study will use Veterans Administration administrative encounter data to examine the prevalence and correlates of prescription of multiple antipsychotic medications in schizophrenia. This data will permit the evaluation of prescribing patterns across a range of inpatient and outpatient facilities covering a vast geographic area. The second and third studies will be conducted in conjunction with two funded NIMH R01 grants. One project will evaluate the modifiable clinician characteristics/behaviors that influence prescription decisions regarding combined antipsychotic regimens in a nation-wide sample of psychiatrists. The new third research project will examine the willingness of psychiatrists to adopt evidence-based treatments for schizophrenia and their preferences for various formats for educational interventions. The fourth study expands the evaluation of prescription decision-making in schizophrenia by focusing on the roles of both the patient and the family in this process. Understanding the patient, clinician, and treatment setting factors that are correlated with antipsychotic polypharmacy, while also uncovering aspects of the cognitive processes involved in prescription decision-making that may be modifiable, will inform the subsequent development of an R01 application aimed at improving the process of prescription decision-making for persons with schizophrenia.
描述(由候选人提供):此修订后的申请概述了 NIMH K01 指导研究科学家发展奖的综合培训和研究计划。我的长期职业目标是制定一项研究计划,重点关注严重精神疾病 (SMI) 患者的药物有效性,其中包括调查典型临床实践环境中药物处方的过程和结果,并将这些知识应用于干预措施的设计,以改善药物处方决策。我的近期职业目标是了解精神分裂症的复杂多药治疗方案(“多药治疗”)的处方,特别关注本应用中的联合抗精神病药物治疗方案。临床医生相关(“供应方”)以及患者和家庭相关(“需求方”)因素同样重要,并且会影响药物管理决策。为了实现这些目标,我将同时完成教学课程和指导培训活动,同时开展研究项目,重点关注处方决策、抗精神病复方用药和调查方法,以及开发改善精神分裂症处方决策的干预措施。这些活动将在来自全国各地的几位在心理健康服务研究、精神药理学以及认知和临床心理学方面具有专业知识的教职人员的指导下进行。提出了四个项目的研究计划。第一项研究将使用退伍军人管理局的行政接触数据来检查精神分裂症中多种抗精神病药物处方的患病率和相关性。这些数据将允许评估覆盖广阔地理区域的一系列住院和门诊设施的处方模式。第二项和第三项研究将与两项 NIMH R01 拨款一起进行。一个项目将评估可修改的临床医生特征/行为,这些特征/行为会影响全国范围内精神科医生样本中联合抗精神病药物治疗方案的处方决策。新的第三个研究项目将调查精神科医生对精神分裂症采取循证治疗的意愿以及他们对各种教育干预形式的偏好。第四项研究通过关注患者和家庭在这一过程中的作用,扩大了精神分裂症处方决策的评估。了解与抗精神病药物复方用药相关的患者、临床医生和治疗环境因素,同时揭示处方决策中可能可修改的认知过程的各个方面,将为后续开发旨在改善精神分裂症患者处方决策过程的 R01 应用程序提供信息。

项目成果

期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Does Adherence to Medications for Type 2 Diabetes Differ Between Individuals With Vs Without Schizophrenia?
  • DOI:
    10.1093/schbul/sbn106
  • 发表时间:
    2010-03-01
  • 期刊:
  • 影响因子:
    6.6
  • 作者:
    Kreyenbuhl, Julie;Dixon, Lisa B.;Valenstein, Marcia
  • 通讯作者:
    Valenstein, Marcia
Long-term antipsychotic polypharmacy in the VA health system: patient characteristics and treatment patterns.
退伍军人事务部卫生系统中的长期抗精神病药物多药治疗:患者特征和治疗模式。
  • DOI:
    10.1176/ps.2007.58.4.489
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kreyenbuhl,JulieA;Valenstein,Marcia;McCarthy,JohnF;Ganoczy,Dara;Blow,FredericC
  • 通讯作者:
    Blow,FredericC
Care and management of cardiovascular risk factors among individuals with schizophrenia and type 2 diabetes who smoke.
吸烟的精神分裂症和 2 型糖尿病患者心血管危险因素的护理和管理。
  • DOI:
    10.1016/j.genhosppsych.2008.07.007
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    7
  • 作者:
    Himelhoch,Seth;Leith,Jaclyn;Goldberg,Richard;Kreyenbuhl,Julie;Medoff,Deborah;Dixon,Lisa
  • 通讯作者:
    Dixon,Lisa
Quality of diabetes care among adults with serious mental illness.
患有严重精神疾病的成年人的糖尿病护理质量。
  • DOI:
    10.1176/ps.2007.58.4.536
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Goldberg,RichardW;Kreyenbuhl,JulieA;Medoff,DeborahR;Dickerson,FaithB;Wohlheiter,Karen;Fang,LiJuan;Brown,ClaytonH;Dixon,LisaB
  • 通讯作者:
    Dixon,LisaB
Physical wellness and employment status among adults with serious mental illness.
患有严重精神疾病的成年人的身体健康和就业状况。
  • DOI:
    10.1007/s10597-008-9124-0
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Goldberg,RichardW;Hackman,Ann;Medoff,DeborahR;Brown,Clayton;Fang,LiJuan;Dickerson,Faith;Kreyenbuhl,Julie;Dixon,Lisa
  • 通讯作者:
    Dixon,Lisa
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JULIE A. KREYENBUHL其他文献

JULIE A. KREYENBUHL的其他文献

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{{ truncateString('JULIE A. KREYENBUHL', 18)}}的其他基金

Addressing Psychiatrist Workforce Shortages in the U.S. with Psychiatric Advanced Practice Registered Nurses
通过精神病学高级执业注册护士解决美国精神科医生劳动力短缺问题
  • 批准号:
    9366319
  • 财政年份:
    2017
  • 资助金额:
    $ 14.33万
  • 项目类别:
A Smartphone Intervention to Improve Adherence to Antipsychotic Medications
智能手机干预可提高抗精神病药物的依从性
  • 批准号:
    8176728
  • 财政年份:
    2011
  • 资助金额:
    $ 14.33万
  • 项目类别:
A Smartphone Intervention to Improve Adherence to Antipsychotic Medications
智能手机干预可提高抗精神病药物的依从性
  • 批准号:
    8322588
  • 财政年份:
    2011
  • 资助金额:
    $ 14.33万
  • 项目类别:
A Smartphone Intervention to Improve Adherence to Antipsychotic Medications
智能手机干预可提高抗精神病药物的依从性
  • 批准号:
    8525456
  • 财政年份:
    2011
  • 资助金额:
    $ 14.33万
  • 项目类别:
Schizophrenia PORT Treatment Recommendations Update 2008
精神分裂症 PORT 治疗建议更新 2008 年
  • 批准号:
    7276994
  • 财政年份:
    2007
  • 资助金额:
    $ 14.33万
  • 项目类别:
Schizophrenia PORT Treatment Recommendations Update 2008
精神分裂症 PORT 治疗建议更新 2008 年
  • 批准号:
    7392645
  • 财政年份:
    2007
  • 资助金额:
    $ 14.33万
  • 项目类别:
Understanding Prescription Decisions in Schizophrenia
了解精神分裂症的处方决定
  • 批准号:
    6618838
  • 财政年份:
    2003
  • 资助金额:
    $ 14.33万
  • 项目类别:
Understanding Prescription Decisions in Schizophrenia
了解精神分裂症的处方决定
  • 批准号:
    6708025
  • 财政年份:
    2003
  • 资助金额:
    $ 14.33万
  • 项目类别:
Understanding Prescription Decisions in Schizophrenia
了解精神分裂症的处方决定
  • 批准号:
    7092573
  • 财政年份:
    2003
  • 资助金额:
    $ 14.33万
  • 项目类别:
Understanding Prescription Decisions in Schizophrenia
了解精神分裂症的处方决定
  • 批准号:
    6864905
  • 财政年份:
    2003
  • 资助金额:
    $ 14.33万
  • 项目类别:

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