Turn it off and on again - exploiting brain hibernation circuits to improve outcomes in critical illness

关闭并再次打开——利用大脑冬眠回路来改善危重疾病的治疗结果

• 批准号: 2897053
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2897053
• 关键词: Turn; off; again; exploiting; brain

Torpor (a brief hibernation) is a remarkable phenomenon exhibited by many animals. It is characterised by extreme physiology including lowered body temperature and heart rate, and immune modulation. As a protective state, torpor is of interest for many clinical and space medicine applications. This project will use mice to characterise the brain circuits that generate each physiological component of torpor to identify potential targets for human medicine and beyond.

冬眠（一种短暂的冬眠）是许多动物都表现出的一种显著现象。它的特点是极端的生理学，包括降低体温和心率，以及免疫调节。作为一种保护性状态，麻痹对于许多临床和空间医学应用都是有意义的。该项目将使用小鼠来模拟产生麻木的每个生理成分的大脑回路，以确定人类医学及其他领域的潜在目标。