Turn it off and on again - exploiting brain hibernation circuits to improve outcomes in critical illness

麻木(一种短暂的冬眠)是许多动物都表现出的一种显著现象。它的特点是极端的生理特征，包括体温和心率降低，以及免疫调节。作为一种保护状态，麻木在许多临床和航天医学应用中具有重要意义。该项目将使用小鼠来描述产生麻木的每一个生理成分的大脑回路，以确定人类医学和其他领域的潜在靶点。

Torpor (a brief hibernation) is a remarkable phenomenon exhibited by many animals. It is characterised by extreme physiology including lowered body temperature and heart rate, and immune modulation. As a protective state, torpor is of interest for many clinical and space medicine applications. This project will use mice to characterise the brain circuits that generate each physiological component of torpor to identify potential targets for human medicine and beyond.