Measuring the Efficacy of Endovascular Treatment of AAA

测量 AAA 血管内治疗的疗效

• 批准号: 7214136
• 负责人: PETER L FARIES
• 金额: $ 6万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-08 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214136
• 关键词: 3-Dimensional; Abdominal Aortic Aneurysm; Aftercare; American; American Heart Association; Aneurysm; Area; Arteries; Blood Vessels; Caliber; Canis familiaris; Cardiac; Cardiology; Cardiovascular system; Cause of Death; Chairperson; Chronic; Cine Magnetic Resonance Imaging; Computers; Development; Devices; Diastole; Doctor of Medicine; Doctor of Philosophy; Effectiveness; Environment; Experimental Models; Fellowship; Implant; Institutes; Invasive; Israel; Laboratories; Laboratory Finding; Legal patent; Magnetic Resonance Imaging; Measures; Medical center; Medicine; Mentored Clinical Scientist Development Award (K08); Mentorship; Methods; Modeling; Monitor; Morbidity - disease rate; Motion; Operative Surgical Procedures; Patients; Perfusion; Porosity; Pressure Transducers; Principal Investigator; Program Development; Range; Research; Research Personnel; Residencies; Resources; Risk; Ruptured Abdominal Aortic Aneurysm; Ruptured Aneurysm; Scientist; Side; Stents; Structure; Supervision; Surgeon; Systole; Techniques; Testing; Thrombus; Time; Training; Training Programs; Translating; Transplanted tissue; Variant; base; career; clinical application; college; day; design; lumbar artery; medical schools; pressure; professor; programs; reconstruction; repaired; size; solid state; success; therapy design; transmission process

DESCRIPTION (provided by applicant): This proposal describes a five year training program for the development of an academic career in Vascular Surgery for the Principal Investigator, who has completed a structured residency in Vascular Surgery at the Beth Israel Deaconess Medical Center / Harvard Medical School and is currently an Assistant Professor of Surgery in the tenure track at the Mount Sinai School of Medicine. The Mentored Scientist Clinical Development Award will support the development of the Principal Investigator, a vascular surgeon who is trained in experimental methods, into an independent investigator. The program will allow him to expand his expertise in vascular surgery research to develop, coordinate and translate laboratory findings into practical clinical applications for the endovascular treatment of patients with abdominal aortic aneurysms. The program will be performed under the mentorship of Valentin Fuster, M.D., Ph.D.. He is the past-president of the American Heart Association, Chairman of the Fellowship Training Directors Program of the American College of Cardiology and Director of the Cardiovascular Institute at the Mount Sinai Medical Center and a Professor of Medicine at the Mount Sinai School of Medicine. He has trained 38 research fellows, many of whom now direct independent laboratories. Juan Badimon, Ph.D., Professor of Medicine, will provide further supervision and training in the areas of thrombus formation and organization. Michael Marin, M.D., Professor of Surgery, a leading pioneer of endovascular stent graft treatment of abdominal aortic aneurysms will enhance the clinical applicability of the hypotheses to be tested. The focus of the research will be measuring the efficacy of endovascular stent graft treatments of abdominal aortic aneurysms. Abdominal aortic aneurysms are a leading cause of death due to aneurysm rupture. Although surgery is the only effective treatment, endovascular surgical techniques utilizing stent grafts have reduced the morbidity of repairing abdominal aortic aneurysms considerably. Endovascular treatments are designed to eliminate arterial perfusion of the aneurysm and thereby eliminate the risk of aneurysm rupture. Although significant advances have been made, the effectiveness of endovascular treatments in eliminating pressure within the aneurysm has not been definitively demonstrated. In addition, no non-invasive means of confirming successful and ongoing elimination of pressure from the aneurysm has been developed. The study will use an experimental model of abdominal aortic aneurysm with an implanted pressure transducer, developed in the principal investigator's laboratory. The effect of retrograde perfusion of the aneurysm sac on intra-aneurysmal pressure after treatment with an endovascular stent graft will be evaluated. The impact of stent graft porosity on the transmission of pressure to the aneurysm will also be studied. Pressure within the aneurysm sac will be correlated with the change in the cross-sectional area and volume of the aneurysm during systole and diastole using cine magnetic resonance imaging. This information may provide a non-invasive means of confirming the success of endovascular stent graft treatment in eliminating pressure from the aneurysm. The rich academic environment provided by the Mount Sinai School of Medicine and the Departments of Surgery and Medicine / Cardiology with the diverse resources and enthusiasm for promoting scientific research will maximize the potential for the principal investigator to establish an academic career as a clinician scientist.

描述(由申请人提供)： 这项提案描述了一项为期五年的培训计划，以发展首席研究员的血管外科学术生涯，他已经完成了在贝丝以色列女执事医学中心/哈佛医学院的血管外科住院医生的结构化培训，目前是西奈山医学院终身教职的外科助理教授。指导科学家临床发展奖将支持首席调查员，一名接受过实验方法培训的血管外科医生，发展成为一名独立的调查员。该计划将使他能够扩大他在血管外科研究方面的专业知识，以开发、协调并将实验室发现转化为实际的临床应用，用于腹主动脉瘤患者的血管内治疗。该项目将在Valentin Fuster医学博士的指导下进行。他是美国心脏协会前主席，美国心脏病学院研究员培训主任计划主席，西奈山医学中心心血管研究所所长，西奈山医学院医学教授。 医学。他已经培训了38名研究员，其中许多人现在是独立实验室的负责人。医学教授胡安·巴迪蒙博士将在血栓形成和组织领域提供进一步的监督和培训。外科教授迈克尔·马林是腹主动脉瘤腔内支架移植治疗的领先先驱，他将提高有待检验的假说的临床适用性。这项研究的重点将是评估腔内支架移植治疗腹主动脉瘤的疗效。腹主动脉瘤是动脉瘤破裂导致死亡的主要原因。虽然手术是唯一有效的治疗方法，但血管内外科技术 使用支架移植物显著降低了腹主动脉瘤修补术的发病率。血管内治疗旨在消除动脉瘤的动脉灌注，从而消除动脉瘤破裂的风险。尽管已经取得了重大进展，但血管内治疗在消除体内压力方面的有效性 动脉瘤还没有得到明确的证实。此外，还没有开发出非侵入性的方法来确认成功和持续地消除了动脉瘤的压力。这项研究将使用首席研究员实验室开发的腹主动脉瘤实验模型，该模型带有植入的压力传感器。这个 我们将评估血管内支架治疗后，动脉瘤囊逆行灌流对动脉瘤内压力的影响。我们还将研究支架移植物孔洞对向动脉瘤传递压力的影响。使用电影磁共振成像技术，动脉瘤囊内的压力将与动脉瘤在收缩和舒张期的横截面积和体积的变化相关联。这一信息可能提供了一种非侵入性手段，以证实血管内支架治疗在消除动脉瘤压力方面的成功。西奈山医学院和外科、医学/心脏病系提供了丰富的学术环境，拥有丰富的资源和促进科学研究的热情，这将最大限度地发挥首席研究人员作为临床科学家建立学术生涯的潜力。