Memristor-based neural interface for massively parallel recording and modulation of neural activity

对完整动物的神经系统进行高信噪比、可扩展和微创的记录和刺激对于促进对大脑功能的理解具有重要意义。细胞外电极是能够与大量神经元连接的最强大的工具之一。神经元组织损伤仍然是电极阵列伸缩的主要限制因素，并已被发现与不同电极材料上的电极尺寸有关。小直径超微电极(UME)虽然非常受欢迎，但在实现与生物信号的充分耦合、限制杂散信号损失以及与读出电子设备的物理接口方面存在重大挑战

High signal-to-noise, scalable and minimally invasive recording and stimulation of the nervous system of intact animals is of fundamental importance to advance the understanding of brain function.Extracellular electrodes are among the most powerful tools capable of interfacing with large neuronal populations. Neuronal tissue damage remains a major limiting factor in scaling electrode arrays and has been found to correlate with electrode size across different electrode materials. Small diameter ultramicroelectrodes (UMEs), while highly desirable, pose significant challenges in reaching sufficient coupling to the bio signal, limiting stray signal loss and physical interfacing with read-out electronics