Transdentinal Induction of Tertiary Dentin

三级牙本质穿牙诱导

• 批准号: 7238620
• 负责人: Mary MacDougall
• 金额: $ 19.59万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7238620
• 关键词: Transdentinal; Induction; Tertiary; Dentin

DESCRIPTION (provided by applicant): The Advanced Dental Restorative Systems (ADRS) program project is collaboration between two institutions, the University Texas Health Science Center and Southwest Research Institute, both in San Antonio, Texas. The ADRS project is a multidiscipline team approach to develop an advanced restorative system that minimizes residual stresses, is tough and fracture-resistant, strengthens tooth structure, protects the pulp, is esthetic and biocompatible, and is suitable as a replacement for amalgam and conventional composite resins. The program consists of five research projects, a technical core and an admin core, with 7 specific aims: 1). Investigate liquid crystal monomers to produce resin materials with near-zero cure shrinkage (Project 1). 2). Investigate surface-modified metal oxide nanoparticles, such as zirconium oxide, metal oxide silicates, and mineral platelets, as a means of producing radiopaque, 'microfiller' particles for development of tough, wear-resistant, homogeneous resin composites (Project 2). 3). Investigate a biomimetic means to induce tertiary dentin as a protective barrier for the pulp, based on delivery of dentin inductive proteins or their analogs into a prepared tooth cavity (Project 3). 4). Investigate the failure modes, and mechanical and physical properties of experimental nanofilled and/or liquid crystal composites in comparison with current clinically successful restorative resins (Project 4). 5). Investigate mechanisms of cytotoxicity and biocompatibility of experimental pulp-protective treatments, nanofilled and/or liquid crystal composites in comparison with current successful clinical restorative materials (Project 5). 6). Develop practical restorative materials through synthesis of nanoparticles and liquid crystal monomers, formulation of these with traditional monomers and fillers, and/or with each other, and supply both materials to other areas of the ADRS program in a timely fashion (Core 2). 7). Develop one or more novel systems for cavity restoration by optimizing the combination of a biomimetic protective pulp barrier technique with a low shrinkage, nanofilled restorative resin (combined outcome of all projects).

描述（由申请人提供）：高级 牙科修复系统（ADRS）计划项目是两个 德克萨斯大学健康科学中心和西南研究中心 研究所，都在德克萨斯州的圣安东尼奥。ADRS项目是一个多学科项目 团队合作开发先进的修复系统，最大限度地减少残留 应力、坚韧和耐磨损性，增强牙齿结构， 保护牙髓，美观且生物相容，适合作为 替代汞齐和传统复合树脂。该方案包括 五个研究项目，一个技术核心和一个行政核心，有7个具体项目 目的： 1）。研究液晶单体以生产树脂材料， 接近零的固化收缩（项目1）。2）。研究表面改性金属 氧化物纳米颗粒，例如氧化锆、金属氧化物硅酸盐，以及 作为产生不透射线的“微填料”颗粒的手段的矿物薄片 用于开发坚韧、耐磨、均匀的树脂复合材料（项目 2）。3）。研究一种仿生方法诱导三级牙本质， 牙髓的保护屏障，基于牙本质诱导蛋白的递送 或其类似物放入准备好的牙腔中（项目3）。4）。探讨 失效模式，以及试验材料的力学和物理性能 纳米填充的和/或液晶复合材料 临床上成功的修复树脂（项目4）。5）。探讨 实验性牙髓保护剂的细胞毒性和生物相容性机制 处理、纳米填充和/或液晶复合材料， 目前成功的临床修复材料（项目5）。6）。发展 通过合成纳米颗粒和液体的实用修复材料 晶体单体，这些单体与传统单体和填料的配方， 和/或彼此，并将这两种材料供应给ADRS的其他区域 及时更新（核心2）。7）。开发一个或多个新系统， 通过优化仿生保护剂组合的空洞修复 低收缩纳米充填修复树脂的牙髓屏障技术 （所有项目的综合结果）。