Transdentinal Induction of Tertiary Dentin

描述(由申请者提供)：高级 牙科修复系统(ADRS)计划项目是两家公司之间的合作 得克萨斯大学健康科学中心和西南研究机构 都在德克萨斯州的圣安东尼奥。ADRS项目是一个多学科的项目 开发最大限度减少残留的高级恢复系统的团队方法 应力强，坚韧，耐折断，强化牙齿结构， 保护牙髓，美观和生物相容，适合作为 替代银汞合金和常规复合树脂。该计划包括 在五个研究项目中，一个是技术核心，一个是管理核心，有7个具体项目 目标： 1)。研究液晶单体以生产树脂材料 近乎零的固化收缩(项目1)。2)。调查表面改性的金属 氧化物纳米颗粒，如氧化锆、金属氧化物硅酸盐和 矿物小片，作为生产不透射线的“微填充”颗粒的一种手段 用于开发坚韧、耐磨、均匀的树脂复合材料(项目 2)。3)。研究一种仿生方法来诱导第三级牙本质作为 基于牙本质诱导蛋白的牙髓保护屏障 或将其类似物制成已准备好的牙洞(项目3)。4)。调查 试验材料的破坏模式、力学和物理性能 纳米颗粒和/或液晶复合材料与电流的比较 临床成功的修复树脂(项目4)。5)。调查 实验性牙髓保护的细胞毒性和生物相容性机制 处理、纳米填充和/或液晶复合材料与 目前成功的临床修复材料(项目5)。6)。发展 纳米颗粒与液体合成的实用修复材料 晶体单体及其与传统单体和填充物的配方， 和/或相互之间，并将这两种材料提供给ADR的其他领域 及时制定计划(核心2)。7)。开发一种或多种新型系统，用于 一种优化组合的仿生保护器修复空洞 低收缩纳米充填修复树脂的牙髓屏障技术 (所有项目的综合成果)。

DESCRIPTION (provided by applicant): The Advanced Dental Restorative Systems (ADRS) program project is collaboration between two institutions, the University Texas Health Science Center and Southwest Research Institute, both in San Antonio, Texas. The ADRS project is a multidiscipline team approach to develop an advanced restorative system that minimizes residual stresses, is tough and fracture-resistant, strengthens tooth structure, protects the pulp, is esthetic and biocompatible, and is suitable as a replacement for amalgam and conventional composite resins. The program consists of five research projects, a technical core and an admin core, with 7 specific aims: 1). Investigate liquid crystal monomers to produce resin materials with near-zero cure shrinkage (Project 1). 2). Investigate surface-modified metal oxide nanoparticles, such as zirconium oxide, metal oxide silicates, and mineral platelets, as a means of producing radiopaque, 'microfiller' particles for development of tough, wear-resistant, homogeneous resin composites (Project 2). 3). Investigate a biomimetic means to induce tertiary dentin as a protective barrier for the pulp, based on delivery of dentin inductive proteins or their analogs into a prepared tooth cavity (Project 3). 4). Investigate the failure modes, and mechanical and physical properties of experimental nanofilled and/or liquid crystal composites in comparison with current clinically successful restorative resins (Project 4). 5). Investigate mechanisms of cytotoxicity and biocompatibility of experimental pulp-protective treatments, nanofilled and/or liquid crystal composites in comparison with current successful clinical restorative materials (Project 5). 6). Develop practical restorative materials through synthesis of nanoparticles and liquid crystal monomers, formulation of these with traditional monomers and fillers, and/or with each other, and supply both materials to other areas of the ADRS program in a timely fashion (Core 2). 7). Develop one or more novel systems for cavity restoration by optimizing the combination of a biomimetic protective pulp barrier technique with a low shrinkage, nanofilled restorative resin (combined outcome of all projects).