Molecular Excitability in the Cardiovascular System

描述（由申请人提供）： 这项培训补助金竞争更新的基本目标和目的，即为4名博士前和5名博士后学生提供心血管生理学方面的出色培训，保持不变。 心血管疾病仍然是发达国家发病率和死亡率的主要原因。 仍然需要优秀的科学家教育工作者来增加我们对心血管疾病的基本理解，并将这些信息转化为临床应用。16名培训教师都是经验丰富的导师，在过去十年中培训了44名博士前学生和89名博士后学生。 教师来自四个不同的部门（3个基础科学，一个临床）与合作的历史。 他们的研究领域从信号分子的原子结构延伸到小鼠心输出量的测量。 集中的领域包括K-通道，烟碱受体，第二信使，肌生成和发育的转录控制，以及心血管疾病的遗传基础。 应用了广泛的技术，包括电生理学、配体结合、荧光光谱学、蛋白质生物化学、荧光成像、共聚焦显微镜、MRI、超声心动图、DNA和蛋白质测序、X射线晶体学、冷冻显微镜和转基因学。 这确保了学员接受综合和跨学科的方法来研究心血管系统的分子兴奋性。 教学课程支持生理学的这一广泛观点，包括分子和细胞生物学以及整个器官生理学课程。 培训计划使受训者具备成为有效教育者的技能。 所有学员定期向教师和学生介绍他们的研究成果，并收到有组织的反馈。 这提高了他们的教学技能，并为他们提供了实践反馈的机会。 我们的学生参加大学范围内的课程和研讨会的教学，科学写作和拨款准备。 在过去的十年中，该计划已培养了54名博士前和博士后学生。 这一成功不仅归功于学生接受的高质量培训，也归功于招收的学生的质量。 我们的培训计划和学院已经制定了计划，积极寻求合格的代表性不足的少数民族。 我们认为，我们的教师，课程和学生的组合将继续产生高质量的科学家，教育工作者。

DESCRIPTION (provided by applicant): The basic goals and objectives of this training grant competing renewal, that is, to provide 4 predoctoral and 5 postdoctoral students with outstanding training in cardiovascular physiology, are unchanged. Cardiovascular disease remains the primary cause of morbidity and mortality in the developed world. There continues to be a need for outstanding scientist-educators to increase our basic understanding of cardiovascular disease and to translate this information into clinical application. The 16 training-faculty are experienced mentors having trained 44 predoctoral and 89 postdoctoral students over the last ten-years. The faculty come from four different departments (3 basic science, one clinical) with a history of collaboration. Their areas of research extend from the atomic structure of signaling molecules to measurements of cardiac output in mice. Areas of concentration include K-channels, nicotinic receptors, second messengers, transcriptional control of myogenesis and development, and genetic bases of cardiovascular disease. A broad range of techniques are applied including electrophysiology, ligand binding, fluorescence spectroscopy, protein biochemicstry, fluorescence imaging, confocal microscopy, MRI, echo cardiography, DNA and protein sequencing, x-ray crystollography, cryomicroscopy, and transgenics. This ensures that trainees receive an integrated and interdisciplinary approach to the study of molecular excitability of the cardiovascular system. The didactic curriculum supports this broad view of physiology and includes classes in molecular and cellular biology as well as whole organ physiology. The training program equips trainees with skills to be effective educators. All trainees regularly present their research findings to the faculty and students and receive organized feedback. This improves their teaching skills as well as gives them opportunities to practice giving feedback. Our students participate in college-wide classes and workshops on didactic teaching, scientific writing and grant preparation. Over the last ten-years the program has trained 54 pre- and postdoctoral students. This success is due not only to the high-quality training that the students receive but also to the quality of the students recruited. Our training program and the college have established programs to aggressively seek qualified under represented minorities. We feel that our combination of faculty, curriculum and students will continue to yield high-quality scientist-educators.