Lipid/Lipoprotein Metabolism and Cardiovascular Diseases

描述(由申请人提供)： 这项申请代表着对田纳西大学健康科学中心的竞争延续，该奖项旨在培训年轻研究人员，研究脂类、脂蛋白、生长因子和激素在心血管生物学和疾病中的作用。该方案的主要目标是：(A)培训年轻研究人员现代科学方法和概念，以便他们能够解决与各种心血管疾病的病因和机制有关的重大问题；(B)鼓励少数族裔和女性科学家的发展，他们对关于脂/脂蛋白、生长因子和激素在各种心血管疾病中的作用的研究感兴趣；(C)加强基础和临床科学家之间的合作，对与心血管疾病有关的共同目标感兴趣；(D)鼓励我们研究所的学生和其他卫生专业人员研究脂/脂蛋白、生长因子和激素在心血管疾病中的作用；以及(E)加强该研究所和中南部地区其他机构的学生和其他青年科学家关于心血管研究重要性的教育。本课程中的专家代表医学系、生理学与生物物理学系和药理学系，以及他们对正常或病理生理心血管功能的研究影响以及信号分子机制的识别。由于这些共性，教官的实验室已经并将继续相互合作。因此，受训者将从正在进行的合作中学习。将提供博士后(5个职位)和博士后(3个职位)级别的培训。除了实验室经验，学员还将参加其他研究活动，如研讨会、期刊俱乐部、访问科学家、临床会议和参加科学会议。我们还打算为博士后实习生提供一些撰写补助金的经验。

DESCRIPTION (provided by applicant): This application represents the competing continuation of an award to the University of Tennessee, The Health Science Center for the training of young investigators in research concerning the role of lipids, lipoproteins, growth factors, and hormones in cardiovascular biology and diseases. The primary objectives of the program are (a) to train young investigators in contemporary scientific methodologies and concepts with which they can address significant questions pertaining to the causes and mechanisms underlying various cardiovascular diseases; (b) to encourage the development of minority and female scientists interested in investigations concerning the role of lipids/lipoproteins, growth factors, and hormones in various cardiovascular diseases; (c) to enhance collaborations between basic and clinical scientists interested in common goals which pertain to cardiovascular diseases; (d) to encourage research in the role of lipids/lipoproteins, growth factors, and hormones in cardiovascular diseases among students and other health professionals at our Institution; and (e) to enhance the education of students, and other young scientists at this Institution and other Institutions in the Mid-South area concerning the importance of cardiovascular research. The preceptors in this program represent Departments of Medicine, Physiology & Biophysics, and Pharmacology and their research impacts upon normal or pathophysiological cardiovascular function as well as the identification of molecular mechanisms of signaling. Because of these commonalties, the preceptors' laboratories have and continue to collaborate with each other. Thus, the trainees stand to learn from ongoing collaborations. Training will be offered at postdoctoral (5 positions) and predoctoral (3 positions) levels. Besides, laboratory experience, the trainees will be exposed to other research activities such as seminars, journal clubs, visiting scientists, clinical conferences, and participation at scientific meetings. It is also our intention to provide postdoctoral trainees some experience in grant writing.