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Lipid/Lipoprotein Metabolism and Cardiovascular Diseases

脂质/脂蛋白代谢与心血管疾病

基本信息

批准号：
7225523
负责人：
KAFAIT U MALIK
金额：
$ 20.76万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-07-01 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7225523
关键词：
Cardiovascular Diseases Lipids Lipoproteins Metabolism

项目摘要

DESCRIPTION (provided by applicant): This application represents the competing continuation of an award to the University of Tennessee, The Health Science Center for the training of young investigators in research concerning the role of lipids, lipoproteins, growth factors, and hormones in cardiovascular biology and diseases. The primary objectives of the program are (a) to train young investigators in contemporary scientific methodologies and concepts with which they can address significant questions pertaining to the causes and mechanisms underlying various cardiovascular diseases; (b) to encourage the development of minority and female scientists interested in investigations concerning the role of lipids/lipoproteins, growth factors, and hormones in various cardiovascular diseases; (c) to enhance collaborations between basic and clinical scientists interested in common goals which pertain to cardiovascular diseases; (d) to encourage research in the role of lipids/lipoproteins, growth factors, and hormones in cardiovascular diseases among students and other health professionals at our Institution; and (e) to enhance the education of students, and other young scientists at this Institution and other Institutions in the Mid-South area concerning the importance of cardiovascular research. The preceptors in this program represent Departments of Medicine, Physiology & Biophysics, and Pharmacology and their research impacts upon normal or pathophysiological cardiovascular function as well as the identification of molecular mechanisms of signaling. Because of these commonalties, the preceptors' laboratories have and continue to collaborate with each other. Thus, the trainees stand to learn from ongoing collaborations. Training will be offered at postdoctoral (5 positions) and predoctoral (3 positions) levels. Besides, laboratory experience, the trainees will be exposed to other research activities such as seminars, journal clubs, visiting scientists, clinical conferences, and participation at scientific meetings. It is also our intention to provide postdoctoral trainees some experience in grant writing.

描述（由申请人提供）：该申请代表了田纳西大学健康科学中心一项奖项的竞争性延续，该奖项旨在培训年轻研究人员进行有关脂质、脂蛋白、生长因子和激素在心血管生物学和疾病中的作用的研究。该计划的主要目标是 (a) 对年轻研究人员进行当代科学方法和概念方面的培训，使他们能够解决与各种心血管疾病的原因和机制有关的重大问题； (b) 鼓励培养对研究脂质/脂蛋白、生长因子和激素在各种心血管疾病中的作用感兴趣的少数族裔和女性科学家； (c) 加强对心血管疾病相关共同目标感兴趣的基础科学家和临床科学家之间的合作； (d) 鼓励我们机构的学生和其他卫生专业人员研究脂质/脂蛋白、生长因子和激素在心血管疾病中的作用； (e) 加强对该机构和中南地区其他机构的学生和其他年轻科学家的关于心血管研究重要性的教育。该项目的导师代表医学、生理学和生物物理学以及药理学系，他们的研究对正常或病理生理性心血管功能以及信号传导分子机制的识别产生影响。由于这些共同点，导师实验室已经并将继续相互合作。因此，学员可以从持续的合作中学习。将提供博士后（5 个职位）和博士前（3 个职位）级别的培训。除了实验室经验外，学员还将接触其他研究活动，如研讨会、期刊俱乐部、访问科学家、临床会议和参加科学会议。我们还打算为博士后学员提供一些资助写作的经验。

项目成果

期刊论文数量（52）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha.

DOI：
10.1016/j.bbalip.2009.08.008
发表时间：
2009-12
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
影响因子：
4.8
作者：
Howell, George, III;Deng, Xiong;Yellaturu, Chandrahassa;Park, Edwards A.;Wilcox, Henry G.;Raghow, Rajendra;Elam, Marshall B.
通讯作者：
Elam, Marshall B.

Activation of membrane protein kinase C by glucagon and Ca(2+)-mobilizing hormones in cultured rat hepatocytes. Role of phosphatidylinositol and phosphatidylcholine hydrolysis.

培养的大鼠肝细胞中胰高血糖素和 Ca(2) 动员激素对膜蛋白激酶 C 的激活。