Promoting self-repair after spinal cord injury

促进脊髓损伤后的自我修复

• 批准号: 2898894
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898894
• 关键词: Promoting; self; repair; after; spinal

Understanding how some organisms successfully repair injured organs and appendages after injury is a long-standing question in the regenerative biology field with profound implications for human health. This is especially true for the spinal cord (SC) given the poor ability of mammals to regenerate their central nervous system. About 27 million people worldwide suffer long-term disability following SC injury (SCI). Depending on the severity of the injury it can cause irreversible damage, which can lead to the loss of motor and sensory function below the site of the damage. This has far reaching consequences for the life of the individual as they face lifelong confinement in wheelchair, dependency on medical care and the risk of premature death. Therefore, there is a high requirement for improving regenerative capabilities of the spinal cord after injury.

了解一些生物如何在受伤后成功修复受损的器官和附属物是再生生物学领域的一个长期问题，对人类健康具有深远的影响。鉴于哺乳动物再生其中枢神经系统的能力较差，脊髓（SC）尤其如此。全世界约有2700万人在SC损伤（SCI）后遭受长期残疾。根据损伤的严重程度，它可能会导致不可逆的损伤，这可能会导致损伤部位以下的运动和感觉功能丧失。这对个人的生活产生了深远的影响，因为他们面临终身坐轮椅、依赖医疗保健和过早死亡的风险。因此，对提高脊髓损伤后的再生能力有很高的要求。