In situ structural characterization of membrane proteins for drug development

用于药物开发的膜蛋白的原位结构表征

• 批准号: 2898988
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898988
• 关键词: situ; structural; characterization; membrane; proteins

This project aims to enable the in situ structural analysis of membrane proteins. Membrane proteins play a crucial role in cellular function and are key drug targets. Understanding how membrane proteins move and function requires insights into both protein and the surrounding environment. In particular, lipids surround membrane proteins and can modulate their structure and function. Detailed knowledge of this modulation remains largely unknown hindering the mechanistic understanding of such drug targets and the development of novel therapeutics.

该项目旨在实现膜蛋白的原位结构分析。膜蛋白在细胞功能中起着至关重要的作用，并且是关键的药物靶标。了解膜蛋白如何移动和功能需要深入了解蛋白质和周围环境。特别是，脂质包围膜蛋白，并可以调节它们的结构和功能。这种调节的详细知识在很大程度上仍然是未知的，阻碍了对这种药物靶点的机理理解和新疗法的开发。