The Perception of Cancer Risk in Patients with Barrett's Esophagus
The Perception of Cancer Risk in Patients with Barrett's Esophagus
批准号:
7260521
负责人:
NICHOLAS J SHAHEEN
金额:
$14.8万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-07-15 至 2009-06-30
关键词:
AddressAdenocarcinomaAnxietyBarrett EsophagusBehaviorBehavioral SciencesBiopsyCancer DetectionCarcinomaCessation of lifeClinic VisitsClinicalClinical Practice GuidelineConditionCross-Sectional StudiesDataDevelopmentDiseaseDysplasiaEducational process of instructingEndoscopyEnvironmentEsophageal AdenocarcinomaEsophagogastric JunctionEsophagusGoalsGrantGuidelinesHealthcareIncidenceInternetInterventionIntestinal MetaplasiaInvestigationKnowledgeLegalMalignant NeoplasmsMeasuresMedical SurveillanceModelingOutcomeOutcome MeasurePatient CarePatient EducationPatientsPatternPerceptionPhysiciansPhysiologicalPopulationPrecancerous ConditionsPreventionProtocols documentationPurposeQuality of lifeResearch PersonnelResourcesRiskSample SizeScreening for cancerScreening procedureSelf-AdministeredSquamous EpitheliumTestingTissuesVisitWorkbasecancer riskcohortdesigneconomic outcomeexperiencehealth beliefhealth care service utilizationhealth related quality of lifeimprovedpatient orientedpreventprogramspsychosocialtherapy designtooltrend
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant):
Barrett's esophagus (BE), defined as the development of intestinal metaplasia in the esophagus, is a premalignant condition that predisposes to adenocarcinoma of the esophagus. The incidence of cancer in the setting of BE without dysplasia is low, approximating 0.005 cases/patient-year. We have previously demonstrated that patients with BE on average greatly overestimate their risk of development of cancer, and that over-estimation of risk was associated with a trend toward increased utilization of resources, such as endoscopy and clinic visits. The objectives of this application are: 1) to assess the perceived risk of esophageal adenocarcinoma in subjects with non-dysplastic BE in a multi-center study, 2) to assess the relationship between risk perception and the utilization of resources in these subjects, and, 3) to develop an internet-based based, self-directed teaching intervention to be administered to subjects with BE in a subsequent RO1 application. The investigators are experienced clinical researchers with a long record of investigation in BE, aided by experts in behavioral sciences. This planning grant would provide a mechanism to confirm observations from preliminary data regarding the overestimation of patients' cancer risk in the setting of Barrett's esophagus, and would examine the association between risk perception and healthcare utilization. It would also provide the means to develop an intervention designed to address patients' misunderstandings of risk, in the framework of a well-validated model of healthcare behavior. This grant will allow refining of disease definitions, outcome measures, sample size, and analysis plans and to address feasibility issues of a subsequent multi-center trial applying the intervention developed in this grant. The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Improving screening practices for Barrett's esophagus.
改善巴雷特食管的筛查实践。
DOI:
10.1016/j.soc.2009.03.007
发表时间:
2009
期刊:
Surgical oncology clinics of North America
影响因子:
1.9
作者:
[Shaheen,NicholasJ, Palmer,LenaB]
通讯作者:
Palmer,LenaB
Advanced a/LCI systems for improved clinical utility
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批准号:9261900
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项目类别:
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依托单位:
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批准号:10049233
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财政年份:2016
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依托单位:
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批准号:9341252
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项目类别:
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财政年份:2013
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依托单位:
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批准号:9139436
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项目类别:
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资助金额:$18.02万
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财政年份:2013
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依托单位:
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批准号:8618302
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财政年份:2013
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依托单位:
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依托单位:
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批准号:7137036
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项目类别:
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财政年份:2006
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依托单位:
Epidemiologic Case-control Study of Barrett's Esophagus
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依托单位:
Epidemiologic Case-control Study of Barrett's Esophagus
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依托单位:
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项目类别:
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依托单位:
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项目类别:
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依托单位:
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项目类别:
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依托单位:
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国内基金
海外基金
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依托单位: