Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy

消融治疗后巴雷特食管的非内镜监测

• 批准号: 8735947
• 负责人: NICHOLAS J SHAHEEN
• 金额: $ 18.14万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-17 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735947
• 关键词: Ablation; Address; Adult; Area; Award; Back; Barrett Esophagus; Biological Assay; Cardiac; Characteristics; Clinical; Clinical Research; Clinical Research Curriculum Award; Cost Effectiveness Analysis; Data; Detection; Development; Devices; Digestive System Disorders; Distal; Distress; Dysplasia; Encapsulated; Endoscopic Biopsy; Endoscopy; Environment; Epidemiology; Epithelium; Esophageal; Esophageal Adenocarcinoma; Esophageal Diseases; Esophageal carcinoma; Esophageal mucous membrane; Esophagus; Exposure to; Faculty; Funding; Gelatin; Goals; Gold; Grant; Hepatology; Incidence; Indolent; Industry; Institution; Institutional National Research Service Award; Internal Medicine; Intervention; Intestinal Metaplasia; Investigation; K-Series Research Career Programs; Lead; Leadership; Lesion; Malignant Neoplasms; Medical Students; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); National Institute of Diabetes and Digestive and Kidney Diseases; Neoplasms; Oral cavity; Patients; Peer Review; Population; Porifera; Precancerous Conditions; Prevention; Procedures; Public Health Schools; Publications; Quality of life; Radiofrequency Interstitial Ablation; Randomized; Recording of previous events; Recurrence; Recurrent disease; Research; Research Methodology; Research Personnel; Research Training; Residencies; Risk; Risk Reduction; Role; Sampling; Schools; Sedation procedure; Sensitivity and Specificity; Structure; Techniques; Time; Translational Research; United States National Institutes of Health; Work; base; capsule; career; career development; comparative effectiveness; cost; cost effective; cost effectiveness; design; effectiveness trial; gastric secretion substance; improved; indexing; medical schools; meetings; minimally invasive; mortality; neoplastic; next generation; novel; outcome forecast; patient oriented research; patient population; professor; programs; prospective; public health relevance; ranpirnase; screening; skills; standard of care; tool; trefoil factor

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award supports Nicholas J. Shaheen, MD, MPH, a Professor of Medicine at UNC, and an Adjunct Professor of Epidemiology at the School of Public Health. Candidate: Dr. Shaheen completed an NIDDK K23 award six years ago, and now is at the midcareer level. He has a highly successful program in patient-oriented research in the prevention, detection and treatment of esophageal neoplasia, with >100 peer-reviewed publications in these areas, an H index of 33, and almost 800 citations of his work in 2012. He has a breadth of research funding, including his role as a PI of NCI's Barrett's Esophagus Translational Research Network (BETRNet), a major project within a U54 grant, co-investigator status on several other NIH grants, and multiple societal & industry grants. Dr. Shaheen has a documented history of successful mentoring of trainees at the medical student, resident and fellow level, including multiple societal and K awards. Twenty of his 31 peer-reviewed publications in 2012 featured trainee authors. This mid-career investigator award will protect Dr. Shaheen's time to focus on patient-oriented research and on mentoring trainees. His immediate objectives are: 1) To expand a rigorous clinical and translational research program in neoplastic conditions of the esophagus; 2) To provide highly structured, appropriately supervised, and fruitful research opportunities for mentees; 3) To enhance his skills in research methodology; 4) To improve his mentoring and leadership skills; and, 5) To provide career development to trainees. His long-term objectives are: 1) To decrease mortality from esophageal carcinoma by improving screening and therapy; 2) To expand the UNC research center for esophageal diseases; and 3) To contribute to the development of the next generation of clinical researchers in digestive diseases. Environment: There is an outstanding pool of potential mentees, due in part to his institution's T32 program in clinical research (R. Sandler, PI). Other mentees come from UNC's highly competitive and academic internal medicine residency, its outstanding School of Public Health, and the School of Medicine. UNC's CTSA award, its K30 program, the School of Public Health and the GI Division's Digestive Diseases Research Center (P30) provide a remarkably rich environment for patient-oriented research training in digestive diseases and hepatology, as evidenced by the multiple successful past trainees of the program. Research: Dr. Shaheen proposes a novel research plan, aimed at addressing the issue of surveillance following endoscopic ablation for dysplastic Barrett's esophagus (BE). Using a recently-developed non-endoscopic device, the Cytosponge, he will perform a comparative effectiveness trial assessing the accuracy of this device in detecting recurrent BE following successful radiofrequency ablation. If this device is able to detect BE in this group, it will open the door for subsequent investigations assessing its utility in other clincal settings. Importantly, given the purposes of this application, this study offers multiple opportunities for the involvement of his mentees, including roles in the design, implementation and analysis of the study. Currently, Dr. Shaheen's mentoring efforts are unfunded, and occur as his clinical duties and research program allow. His current funding protects no time for mentoring. Given the expansion of both his research program and the clinical requirements of his institution, mentoring is becoming more difficult. This K24 award will provide essential support for the candidate to meet his mentoring and research goals.

描述（由申请人提供）：这个K24中期职业研究者奖支持尼古拉斯·J·沙欣，医学博士，公共卫生硕士，医学教授，公共卫生学院流行病学兼职教授。候选人：沙欣博士六年前完成了NIDDK K23奖，现在处于职业生涯中期。他在以患者为导向的食管肿瘤预防、检测和治疗研究方面有一个非常成功的项目，在这些领域有超过100篇同行评议的出版物，H指数为33，2012年他的工作被引用近800次。他拥有广泛的研究资金，包括他作为NCI的巴雷特食管转化研究网络（BETRNet）的PI的角色，这是U 54赠款中的一个主要项目，其他几个NIH赠款的共同研究者身份，以及多个社会和行业赠款。 博士Shaheen有记录的成功指导实习生的历史，在医学生，居民和研究员的水平，包括多个社会和K奖。2012年，他发表了31篇同行评议的论文，其中有20篇以实习作者为特色。这项职业生涯中期的研究者奖将保护沙欣博士的时间，专注于以病人为导向的研究和指导学员。他的近期目标是：1）在食管肿瘤条件下扩大严格的临床和转化研究计划; 2）为学员提供高度结构化，适当监督和富有成效的研究机会; 3）提高他在研究方法方面的技能; 4）提高他的指导和领导能力;以及，5）为学员提供职业发展。他的长期目标是：1）通过改善筛查和治疗来降低食管癌的死亡率; 2）扩大食管疾病研究中心; 3）为下一代消化系统疾病临床研究人员的发展做出贡献。环境：有一个优秀的潜在学员池，部分原因是他的机构的T32临床研究计划（R。桑德勒，PI）。其他学员来自麻省理工学院极具竞争力和学术性的内科住院医师，其杰出的公共卫生学院和医学院。CTSA奖，其K30计划，公共卫生学院和GI部门的消化疾病研究中心（P30）为消化疾病和肝病学以患者为导向的研究培训提供了非常丰富的环境，该计划的多个成功的过去学员证明了这一点。研究：Shaheen博士提出了一项新的研究计划，旨在解决异型增生Barrett食管（BE）内镜消融后的监测问题。使用最近开发的非内窥镜器械Cytosponge，他将进行一项比较有效性试验，评估该器械在成功射频消融后检测复发性BE的准确性。如果该器械能够检测该组中的BE，则将为后续研究打开大门，评估其在其他临床环境中的效用。重要的是，鉴于本申请的目的，本研究为他的学员提供了多种参与机会，包括在研究的设计，实施和分析中的作用。目前，Shaheen博士的指导工作没有资金支持，并在他的临床职责和研究计划允许的情况下进行。他目前的资金保障没有时间进行指导。鉴于他的研究计划和他所在机构的临床要求的扩大，指导变得越来越困难。这个K24奖项将为候选人提供必要的支持，以实现他的指导和研究目标。