Bioscience Research Integration Software Platform

描述（由申请人提供）： 现在比以往任何时候都更加清楚地需要调查和了解与疾病有关的生物信息的所有要素。然而，当今技术产生的大量非整合数据阻止了科学家有效地将这些数据转化为有意义的发现。因此，通过生物科学研究收集的大量数据没有标准化，无法在实验室之间或实验室内部进行整合，而联邦政府资助的研究提供的原始数据相对较少，尽管法规要求这样做。同样，研究人员经常希望合作，但由于缺乏方便的手段而没有合作。 我们的使命是通过完成原型软件应用程序LabmatrixTM来提高面向临床的基础生命科学研究的生产力。LabmatrixTM将为分子、基因组和临床数据的收集、操作和相互关联提供一个基于软件的平台，从而提高发现和验证分子靶点的效率。除了为生命科学家完成一个引人注目的软件工具，在两个有代表性的测试实验室实施之前，期间和之后收集适当的数据将使我们能够确定这种软件对生产力的影响。第一阶段，具体目标1将在两个测试实验室完成当前科学实践评估协议的设计，整合项目团队所有成员的观点，包括一般生产力，信息安全，参考数据的使用，工作流程和计算机用户交互。第一阶段，具体目标2a将使用具体目标1中创建的工具完成对两个代表性生物科学实验室的科学实践的评价。第I阶段，具体目标2b将评估当前LabmatrixTM软件开发工具和实践。第一阶段，具体目标3将比较评估期间确定的生物科学生产力和满意度的关键要素与Labmatrix TM早期原型中的现有支持，并将记录新的要求。第一阶段，具体目标4a将发展具体目标2b中确定的基于软件开发工具和实践的使用，并将建立定期观察/文档周期以衡量其影响。第一阶段，具体目标4 b将完成第二阶段实施所需的软件实践变更。第一阶段，具体目标5实施LabmatrixTM的关键功能，以优化在各种生物科学实验室中实施的便利性。LabmatrixTM的关键创新是将实验室中常见的科学实践捕获到一个集成的软件包中，从而实现数据的广泛共享和重复使用，这是实验室实践工作流程管理的一个步骤，但在该行业尚未完全完成。与这些特定目标相关的里程碑的实现将标志着第一阶段的结束和第二阶段的开始，LabmatrixTM将通过两个测试实验室的持续交互式软件开发准备商业发布。

DESCRIPTION (provided by applicant): The need to investigate and understand all elements of biological information pertinent to disease is more clearly evident now than ever before. However, the avalanche of non-integrated data produced by today's technologies prevents scientists from effectively reducing these data to meaningful discoveries. As a result, the vast bulk of data collected through bioscience research are not standardized and cannot be integrated between or within laboratories, and relatively few raw data are available from federally-funded research, despite a regulation requiring it. In the same vein, researchers often wish to collaborate, but do not because they lack a convenient means to do so. Our mission is to improve clinically-oriented basic life science research productivity by completing a prototype software application, LabmatrixTM. LabmatrixTM will provide a software-based platform for the collection, manipulation and interrelation of molecular, genomic and clinical data that results in increased efficiency in discovering and validating molecular targets. In addition to completion of a compelling software tool for life scientists, the collection of appropriate data before, during, and after implementation in two representative Test Laboratories will allow us to ascertain the impact on productivity of such software. Phase I, Specific Aim 1 will complete design of a current scientific practices evaluation protocol in two test laboratories, integrating viewpoints from all members of the project team, including general productivity, information security, use of reference data, workflow, and computer-user interactions. Phase I, Specific Aim 2a will complete evaluation of scientific practices in two representative bioscience laboratories using the tool created in Specific Aim 1. Phase I, Specific Aim 2b will evaluate current LabmatrixTM software development tools and practices. Phase I, Specific Aim 3 will compare key elements of bioscience productivity and satisfaction identified during the evaluation period to existing support in the LabmatrixTM early prototype, and will document new requirements. Phase I, Specific Aim 4a will evolve the use of empirically-based software development tools and practices identified in Specific Aim 2b, and will establish a regular observation/documentation cycle to measure their impact. Phase I, Specific Aim 4b will complete software practice changes needed for implementation in Phase II. Phase I, Specific Aim 5 implements key features of LabmatrixTM to optimize the ease of implementation in varied bioscience laboratories. The key LabmatrixTM innovation is the capture of scientific practices common across labs into one integrated software package that enables broad sharing and re-use of data, a step in laboratory practices workflow management not yet fully accomplished in this industry. Achievement of milestones linked to these Specific Aims will mark the end of Phase I and commencement of Phase II, where LabmatrixTM will be readied for commercial launch through continued interactive software development in two test laboratories.