Lightweight Ambient Pressure & Temperature Oxygen Concentrator (LAPTOC)

描述（由申请人提供）：该II期项目的目标是为COPD患者提供负担得起且不显眼的便携式氧气供应。长期氧疗（LTOT）--持续吸氧结合运动--显著提高了这些患者的存活率。开发一种不干扰正常日常活动的安全电池供电器械将促进患者对治疗的依从性并提高其生活质量。该研究项目支持NHLBI的使命，即指导与肺部疾病患者的治疗和康复相关的设备开发研究。正在开发的便携式制氧机重量将不到1.5公斤，但将提供所需的2-3升每分钟（Lpm）的等效氧气流量为6小时。与现有便携式集中器相比，这种显着的性能改进将通过重新设计集中器架构来实现。三维原型将用于创建能量存储，动力传输和惯性阻尼组件，这些组件共享功能，从而减少设备质量。SDGroup和其他公司正在开发的快速动力学空气分离吸附剂将能够应用专有的快速循环、能量回收设计，将输送氧气的功耗降低到15 W/Lpm。将开发自适应功率控制算法，以协调传感器输入、患者数据和保存功能。患者数据日志将集成到设备中，允许呼吸科临床医生确认依从性和个性化治疗。慢性阻塞性肺疾病（COPD）困扰着美国超过1250万人，是第四大死亡原因。运动结合持续氧疗已被证明是最有效的治疗这种疾病。该项目将开发一种极其紧凑、轻便和安静的便携式制氧机，以提高患者的依从性，并改善需要长期氧疗（LTOT）的低氧性COPD患者的生活质量。

DESCRIPTION (provided by applicant): The objective of this Phase II project is to provide an affordable and unobtrusive portable oxygen supply for COPD patients. Long term oxygen therapy (LTOT)-continuous oxygen combined with exercise-dramatically increases survival rates for these patients. Development of a safe battery operated device that does not interfere with normal daily activities will promote patient compliance with therapy and enhance their quality of life. This research project supports the NHLBI's mission to direct research in the development of devices related to the treatment and rehabilitation of patients suffering from lung disease. The portable oxygen concentrator under development will weigh less than 1.5 kg, yet will deliver the required 2-3 liters per minute (Lpm) equivalent oxygen flow for a period of 6 hours. This dramatic performance improvement over existing portable concentrators will be achieved by re-engineering the concentrator architecture. Three dimensional prototyping will be used to create energy storage, power transmission, and inertial damping components that share functionalities and thus reduce device mass. Fast kinetics air separation adsorbents being developed as SDGroup and elsewhere will enable the application of a proprietary rapid cycle, energy recuperative design that reduces power consumption to 15W/Lpm delivered oxygen. Adaptive power control algorithms will be developed to coordinate sensor input, patient data, and conserver functions. A patient data log will be integrated into the device, allowing the respiratory clinician to confirm compliance and personalize therapy. Chronic Obstructive Pulmonary Disease (COPD) afflicts over 12.5 million people in US and is the fourth leading cause of death. Exercise combined with continuous oxygen therapy has been shown to be the most effective treatment for this disease. This project will develop an extremely compact, lightweight and quiet portable oxygen concentrator that will augment patient compliance and improve quality of life for hypoxemic COPD patients requiring long term oxygen therapy (LTOT).