Lightweight Ambient Pressure & Temperature Oxygen Concentrator (LAPTOC)

轻质环境压力

• 批准号: 7323638
• 负责人: ROBERT B LACOUNT
• 金额: $ 41.82万
• 依托单位: SEPARATION DESIGN GROUP, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7323638
• 关键词: Activities of Daily Living; Adsorption; Air; Algorithms; Architecture; Area; Biological Sciences; Cardiac; Caring; Cause of Death; Cells; Chronic; Chronic Obstructive Airway Disease; Collaborations; Complex; Consumption; Coupled; Daily; Data; Development; Device or Instrument Development; Devices; Disease; Electronics; Engineering; Exercise; Exhibits; Gases; Goals; Health; Home environment; Hour; Hypoxemia; International; Joints; Kinetics; Left; Life; Liquid substance; Lung diseases; Manufacturer Name; Marketing; Mechanics; Medical; Medical Device; Medical center; Medicine; Methods; Mission; Nitrogen; Noise; Operative Surgical Procedures; Output; Oxygen; Oxygen Therapy Care; POMC gene; Pathway interactions; Patients; Performance; Phase; Phase III Clinical Trials; Physician Executives; Process; Quality of life; Rate; Rehabilitation therapy; Reporting; Research; Research Project Grants; Safety; Sleep; Speed; Structure; Survival Rate; System; Technology; Temperature; Time; Transportation; Travel; Universities; Walking; Weight; Work; base; body system; college; commercialization; compliance behavior; design; ergonomics; improved; manufacturing process; novel strategies; p27 Cell Cycle Protein; p27 Enzyme Inhibitor; pressure; programs; respiratory; restoration; sensor; transmission process; wasting

DESCRIPTION (provided by applicant): The objective of this Phase II project is to provide an affordable and unobtrusive portable oxygen supply for COPD patients. Long term oxygen therapy (LTOT)-continuous oxygen combined with exercise-dramatically increases survival rates for these patients. Development of a safe battery operated device that does not interfere with normal daily activities will promote patient compliance with therapy and enhance their quality of life. This research project supports the NHLBI's mission to direct research in the development of devices related to the treatment and rehabilitation of patients suffering from lung disease. The portable oxygen concentrator under development will weigh less than 1.5 kg, yet will deliver the required 2-3 liters per minute (Lpm) equivalent oxygen flow for a period of 6 hours. This dramatic performance improvement over existing portable concentrators will be achieved by re-engineering the concentrator architecture. Three dimensional prototyping will be used to create energy storage, power transmission, and inertial damping components that share functionalities and thus reduce device mass. Fast kinetics air separation adsorbents being developed as SDGroup and elsewhere will enable the application of a proprietary rapid cycle, energy recuperative design that reduces power consumption to 15W/Lpm delivered oxygen. Adaptive power control algorithms will be developed to coordinate sensor input, patient data, and conserver functions. A patient data log will be integrated into the device, allowing the respiratory clinician to confirm compliance and personalize therapy. Chronic Obstructive Pulmonary Disease (COPD) afflicts over 12.5 million people in US and is the fourth leading cause of death. Exercise combined with continuous oxygen therapy has been shown to be the most effective treatment for this disease. This project will develop an extremely compact, lightweight and quiet portable oxygen concentrator that will augment patient compliance and improve quality of life for hypoxemic COPD patients requiring long term oxygen therapy (LTOT).

描述（由申请人提供）：该第二阶段项目的目标是为慢性阻塞性肺病患者提供负担得起且不引人注目的便携式氧气供应。长期氧疗（LTOT）——持续吸氧结合运动——可显着提高这些患者的生存率。开发一种不会干扰正常日常活动的安全电池供电设备将促进患者对治疗的依从性并提高他们的生活质量。该研究项目支持 NHLBI 的使命，即指导与肺病患者的治疗和康复相关的设备开发研究。正在开发的便携式制氧机重量不到 1.5 公斤，但可提供 6 小时内所需的每分钟 2-3 升 (Lpm) 等效氧气流量。与现有便携式集中器相比，性能的显着提高将通过重新设计集中器架构来实现。三维原型设计将用于创建共享功能的能量存储、电力传输和惯性阻尼组件，从而减少设备质量。 SDGroup 和其他公司正在开发的快速动力学空气分离吸附剂将能够应用专有的快速循环、能量回收设计，将输送氧气的功耗降低至 15W/Lpm。将开发自适应功率控制算法来协调传感器输入、患者数据和保护功能。患者数据日志将集成到设备中，使呼吸临床医生能够确认依从性并进行个性化治疗。慢性阻塞性肺疾病 (COPD) 困扰着美国超过 1250 万人，是第四大死因。运动结合持续氧疗已被证明是治疗这种疾病的最有效方法。该项目将开发一种极其紧凑、轻便且安静的便携式制氧机，它将增强患者的依从性，并改善需要长期氧疗 (LTOT) 的低氧 COPD 患者的生活质量。