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Cu-catalysed Amination of Alkylboron Reagents

铜催化烷基硼胺化试剂

基本信息

批准号：
2902162
负责人：
金额：
--
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2902162
关键词：
Cu catalysed Amination Alkylboron Reagents

项目摘要

The aim of this Ph.D. project is to develop Cu-catalyzed methods for the amination ofalkylboronic esters and to investigate their potential applications in biological systems.Alkylborons are valuable reagents in organic synthesis, owing to their versatileproperties as building blocks for the preparation of organic molecules. These compoundsare stable in air and moisture and exhibit broad compatibility and reactivity with variousfunctional groups. The Partridge group has directed its efforts toward developing novelC-N bond-forming reactions through the interaction of alkylboronic esters and amines,thereby generating amine-containing compounds. This chemistry is particularly useful forsynthesizing biologically active compounds, including pharmaceuticals, agrochemicals, andnatural products.The outcomes of this research are expected to have significant implications for thepharmaceutical and rapidly expanding bioscience sectors. By enabling the discovery andpreparation of probes for exploring biological systems and developing new treatments, theproject is crucial for the UK's economy and the health and wellbeing of its population.Given the strength of the UK's organoboron chemistry expertise, this project isanticipated to further enhance the country's reputation in this area internationally.Through this Ph.D. project, students will acquire extensive experience in syntheticorganic chemistry and catalysis, encompassing multi-step synthesis, methodology, andATAS CERTIFICATEanalytical techniques for compound characterization. The developed chemistry is expectedto find applications primarily in the agrochemical and pharmaceutical industries.

这个博士学位的目的。本项目的主要目的是发展铜催化的烷基硼酸酯的胺化反应，并研究其在生物体系中的潜在应用。这些化合物在空气和水分中稳定，并与各种官能团表现出广泛的相容性和反应性。Parabolic集团致力于开发新型C-N键形成反应，通过烷基硼酸酯和胺的相互作用，从而产生含胺化合物。这种化学方法对于合成生物活性化合物特别有用，包括药物，农用化学品和天然产物。这项研究的结果预计将对制药和迅速发展的生物科学部门产生重大影响。通过发现和制备用于探索生物系统和开发新治疗方法的探针，该项目对英国的经济及其人口的健康和福祉至关重要。鉴于英国有机硼化学专业知识的实力，该项目有望进一步提高该国在该领域的国际声誉。项目，学生将获得合成有机化学和催化方面的丰富经验，包括多步合成，方法学和ATAS CERTIFICATE分析技术的化合物表征。发展起来的化学有望主要在农业化学和制药工业中找到应用。