Cu-catalysed Amination of Alkylboron Reagents

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The aim of this Ph.D. project is to develop Cu-catalyzed methods for the amination ofalkylboronic esters and to investigate their potential applications in biological systems.Alkylborons are valuable reagents in organic synthesis, owing to their versatileproperties as building blocks for the preparation of organic molecules. These compoundsare stable in air and moisture and exhibit broad compatibility and reactivity with variousfunctional groups. The Partridge group has directed its efforts toward developing novelC-N bond-forming reactions through the interaction of alkylboronic esters and amines,thereby generating amine-containing compounds. This chemistry is particularly useful forsynthesizing biologically active compounds, including pharmaceuticals, agrochemicals, andnatural products.The outcomes of this research are expected to have significant implications for thepharmaceutical and rapidly expanding bioscience sectors. By enabling the discovery andpreparation of probes for exploring biological systems and developing new treatments, theproject is crucial for the UK's economy and the health and wellbeing of its population.Given the strength of the UK's organoboron chemistry expertise, this project isanticipated to further enhance the country's reputation in this area internationally.Through this Ph.D. project, students will acquire extensive experience in syntheticorganic chemistry and catalysis, encompassing multi-step synthesis, methodology, andATAS CERTIFICATEanalytical techniques for compound characterization. The developed chemistry is expectedto find applications primarily in the agrochemical and pharmaceutical industries.