Neural and Pharmacological Mechanisms of Abused Drugs

滥用药物的神经和药理学机制

• 批准号: 7232929
• 负责人: KENNETH Maurice JOHNSON
• 金额: $ 16.94万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232929
• 关键词: drug of abuse; relating to nervous system

DESCRIPTION (provided by applicant): Substance abuse and dependence remain alarming social and health concerns in the U.S. and the world. The successful development of treatment medications that are readily accessible and support patient compliance must be based on a clear understanding of the mechanisms of action underlying the effects of abused drugs and the progression to addiction, as well as the development and validation of new chemical moieties with promise as medications. In this competing renewal, we propose to train two pre- and two postdoctoral fellows in the pursuit of these goals. The NIDA Training Program at the University of Texas Medical Branch (UTMB) has been funded since 1994 and has trained a total of 14 pre- and 11 post-doctoral fellows who utilize their knowledge for basic, clinical and translational research, teaching and/or clinical care in academic or industrial settings. The Training Program is supported within the exemplary UTMB infrastructure and graduate programs, under the UTMB Center for Addiction Research umbrella, and benefits from the recruitment of a concentration of faculty and chemists in the new UTMB Program in Chemical Biology. The interdisciplinary interests of the 21 Program Faculty from multiple departments span basic and translational initiatives, including the neurobiology of amino acids, monoamines and neuro-modulators, their roles in the biological effects of abused drugs and the progression to addiction; drug discovery and medications development in addiction, pain management and infectious disease; fetal exposure to medications during pregnancy in opiate addicts; HIV/AIDS associated neuropathy and interactions between HIV and drug addiction. The Program will provide exemplary opportunities for research training within clusters of transdisciplinary collaborations on questions in addiction and offers an attractive, challenging curriculum. Given the growing interest in translational research, a new goal of the Training Program is to provide opportunities for exposure to clinical research and translational thought. A wider appreciation for addiction specific issues will be fostered through journal clubs, workgroups, seminars, and opportunities to interact with experts in the research, treatment and prevention arenas. Laboratory and didactic training will be augmented by program activities that develop the professional skills needed for advancement towards an independent career. The culmination of our efforts is the success of our trainees as complete, contemporary scientists equipped with the tools to advance the mechanistic understanding of addiction and move these advances toward new therapeutic approaches to its treatment. Few effective, accessible medications for the treatment of substance abuse and dependence are currently available. Through clinical and laboratory methods, we will train the next generation of young investigators dedicated to uncover mechanisms underlying chemical dependency and develop new therapeutic medications for treatment.

描述（由申请人提供）：在美国和世界上，滥用药物和依赖仍然令人震惊。易于获取和支持患者依从性的治疗药物的成功开发必须基于对滥用药物影响和成瘾进展的作用机制的清晰了解，以及具有有望作为药物的新化学部分的开发和验证。在这种竞争的续约中，我们建议培训两个前和两个博士后研究员，以追求这些目标。德克萨斯大学医学分支机构（UTMB）的NIDA培训计划自1994年以来已被资助，并在学术或工业环境中利用其知识用于基本，临床和转化研究，教学和/或临床护理，总共培训了14名博士后和11名博士后研究员。在UTMB成瘾研究伞下的示例性UTMB基础设施和研究生计划中，该培训计划得到了支持，并在新的UTMB化学生物学计划中招募了教职员工和化学家的招聘受益。来自多个部门的21个计划教师的跨学科利益涵盖了基本和转化计划，包括氨基酸，单胺和神经调节剂的神经生物学，它们在滥用药物的生物学作用中的作用以及成瘾的进展；药物发现和药物成瘾，疼痛管理和传染病的发展；阿片类药物怀孕期间胎儿接触药物；艾滋病毒/艾滋病相关的神经病和艾滋病毒与药物成瘾之间的相互作用。该计划将在成瘾问题的跨学科合作群中为研究培训提供典范的研究培训，并提供有吸引力的，具有挑战性的课程。鉴于对翻译研究的兴趣日益增长，培训计划的新目标是为接触临床研究和转化思想的机会提供机会。通过期刊俱乐部，工作组，研讨会以及与研究，治疗和预防领域的专家互动的机会，将培养人们对成瘾特定问题的更广泛的欣赏。计划活动将增强实验室和教学培训，这些活动将发展为独立职业所需的专业技能。我们努力的最高峰是我们的学员的成功，具有完整的当代科学家，配备了能够提高对成瘾的机械理解的工具，并将这些进步推向新的治疗方法。目前，很少有有效的，可访问的药物用于治疗药物滥用和依赖性。通过临床和实验室方法，我们将培训下一代的年轻研究人员，致力于发现化学依赖性的机制，并开发出新的治疗药物进行治疗。