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HEMOGLOBIN and BLOOD PROTEIN CHEMISTRY

HEMOGLOBIN and BLOOD PROTEIN CHEMISTRY
血红蛋白和血蛋白化学
批准号:
7486083
负责人:
ELIZABETH A. KOMIVES
金额:
$3.35万
依托单位国家:
美国
项目类别:
财政年份:
1976
资助国家:
美国
项目状态:
已结题
起止时间:
1976-07-01 至 2011-08-31

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中文摘要
翻译
血红蛋白和血液蛋白化学的培训计划为化学家提供培训, 血蛋白、血液蛋白和循环蛋白的生物化学家、生物药理学家和生物学家 专注于化学研究。培训教师积极从事电子转移的研究 在蛋白质内,氧与血红素蛋白的结合,膜包埋蛋白的结构, 参与调控过程的蛋白质结构,细胞免疫学,转录调控和 凝结过程他们提供超快动力学,X射线晶体学,核磁共振,蛋白质 化学、基因调节、免疫化学和血液的调节性翻译后修饰 proteins.学员有机会透过 培训计划的跨学科性质。培训方案为以下人员提供了一个连续的场所: 加州圣地亚哥大学的跨学科培训,将主要校园部门联系起来 和医学院翻译研究培训一直是该组织的长期目标之一。 程序 25名培训教师来自不同的课程,包括化学和生物化学(15), 生物学(2)、物理学(2)、医学(2)和药理学(4)。从历史上看,该计划的重点是 生物物理化学应用于血红素蛋白和血液蛋白,这解释了更大的 来自化学和生物化学系的贡献。 申请资助的六名博士预科生将根据他们的研究进行挑选 兴趣和记录的研究进展,从一个大的研究生就读于 参与部门的研究生课程。五名博士后培训人员的支持是 将根据他们以前的研究贡献和他们的相关性进行选择。 从申请加入的候选人中推荐血红蛋白和血液蛋白的研究 培训教师的研究计划。 培训是通过参与教师的指导下,通过实验室研究提供, 在参与部门的正式讲座课程,通过定期安排的部门和小 小组研讨会,并通过使用仪器的个人培训。博士预科课程的持续时间 培训一般为三年,博士后培训一般为两年。
英文摘要
The training program in Hemoglobin and Blood Protein Chemistry provides training to chemists, biochemists, biophysicists, and biologists in hemoproteins, blood proteins, and circulating proteins concentrating on chemical studies. The training faculty are actively engaged in studies of electron transfer within proteins, oxygen binding to hemoproteins, the structure of membrane-embedded proteins, the structure of proteins involved in regulatory processes, cellular immunology, transcriptional regulation and coagulation processes. They provide training in ultra fast kinetics, X-ray crystallography, NMR, protein chemistry, gene regulation, immunochemistry and regulatory post-translational modifications of blood proteins. The trainees have the opportunity to receive training in a wide array of techniques through the interdisciplinary nature of the training program. The training program has provided a continuous venue for interdisciplinary training at the University of California San Diego that bridges the main campus departments and the School of Medicine. Translational research training has been one of the long-standing goals of the program The twenty-five training faculty are from diverse programs including Chemistry and Biochemistry (15), Biology (2), Physics (2), Medicine (2) and Pharmacology (4). Historically, the emphasis of the program has been the application of biophysical chemistry to hemoproteins and blood proteins, which explains the larger contribution from the Department of Chemistry and Biochemistry. The six predoctoral trainees for which support is requested will be selected on the basis of their research interests and documented progress in research from a large pool of graduate students enrolled in the graduate programs of the participating departments. The five postdoctoral trainees for which support is requested will be selected on the basis of their previous research contributions and relevance of their proposed research to Hemoglobin and Blood Proteins from among candidates who have applied to join the research programs of training faculty. Training is provided through laboratory research under the direction of the participating faculty, through formal lecture courses in the participating departments, through regularly scheduled departmental and small group seminars, and through individual training in the use of instrumentation. The duration of the predoctoral training is typically three years, and the duration of the postdoctoral training is typically two years.
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