Molecular Biophysics Training Grant at UC San Diego

加州大学圣地亚哥分校分子生物物理学培训补助金

• 批准号: 10615137
• 负责人: ELIZABETH A. KOMIVES
• 金额: $ 49.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615137
• 关键词: Biophysics; Grant; Molecular; Training

ABSTRACT. The goal of the Molecular Biophysics Training Grant (MBTG) at the University of California San Diego is to provide a rigorous and strongly interdisciplinary training program for graduate students, with the aim of training the next generation of scientific leaders striving to solve important biological problems using Molecular Biophysics approaches. To accomplish this goal, trainees with strong quantitative backgrounds and a demonstrated aptitude, commitment, and passion for research are selected at the end of their first year from a diverse group of applicants from 32 well-funded training faculty labs. The MBTG faculty are highly interdisciplinary and many have cross-campus appointments in several departments. Trainees come mostly from two graduate programs, Chem/Biochem and Biomedical Sciences but a few come from Physics, Biology and Bioengineering. During their first year, all students engage in research rotations and choose a research lab. At UCSD, students are free to rotate with any faculty across campus and to choose any faculty for their thesis advisor. First year students receive training from their respective graduate programs in critical reading of literature, exposure to important unsolved biological problems, ethics and graduate school survival skills. MBTG Trainees are appointed and choose their thesis committee at the end of their first year. All MBTG trainees take two rigorous core courses in Molecular Biophysics and will have an intensive week-long Statistics workshop. During their second year, they write and defend their thesis research proposal. Required trainee activities include a full-length seminar presentation of their research at the monthly student seminar, monthly discussions of rigor and reproducibility, a monthly journal club, a yearly retreat, career workshops and outside mentors. Trainees may apply to be reappointed for a maximum of two years of support. All trainees present their research every year at the annual retreat, with alumni trainees giving lightning talks each year until graduation. Throughout their graduate training, trainees take advantage of career development opportunities and mentorship, including yearly IDPs and group and individual engagement with outside mentors. The program emphasizes the development of creative independent thinking, strong quantitative skills with a focus on rigor and reproducibility, scientific communication, and mentoring. The MBTG provides the critical interdisciplinary “home” at UCSD for students and faculty interested in Molecular Biophysics. The high quality of student publications, postdoctoral fellowships, faculty positions, and industry positions obtained by our trainees are strong evidence of successful training outcomes. Given the depth, quality, and diversity of our student pool and our demonstrated training outcomes, we request 12 students be supported each year.

摘要。加州大学旧金山分校的分子生物物理学培训基金（MBTG）的目标是 迭戈是为研究生提供一个严格的和强烈的跨学科的培训计划，目的是 培养下一代科学领导者，努力利用分子生物学解决重要的生物学问题。 生物物理学方法。为了实现这一目标，具有较强的量化背景和 表现出的才能，承诺和对研究的热情是在他们的第一年年底从一个 来自32个资金充足的培训教师实验室的多元化申请者群体。MBTG的教师们高度重视 跨学科，许多人在几个部门跨校园任命。学员主要来自 两个研究生课程，化学/生物化学和生物医学科学，但少数来自物理，生物和 生物工程。在他们的第一年，所有的学生从事研究轮换，并选择一个研究实验室。在 UCSD，学生可以自由地与校园内的任何教师轮换，并选择任何教师为他们的论文 顾问.一年级的学生从各自的研究生课程中接受批判性阅读的培训， 文学，接触重要的未解决的生物学问题，道德和研究生院生存技能。MBTG 学员在第一年结束时被任命并选择他们的论文委员会。所有MBTG学员都需要 在分子生物物理学两个严格的核心课程，并将有一个为期一周的密集的统计研讨会。 在他们的第二年，他们写和捍卫他们的论文研究建议。所需的受训人员活动包括 在每月的学生研讨会上展示他们的研究成果，每月的严谨讨论 和可重复性，一个月刊俱乐部，一个年度务虚会，职业讲习班和外部导师。学员 可申请重新任命，最多支持两年。所有学员每隔一周 在一年一度的退修会上，校友学员每年都会举行闪电讲座，直至毕业。在其整个 毕业生培训，学员利用职业发展机会和指导，包括每年 国内流离失所者以及团体和个人与外部导师的接触。该方案强调发展 具有创造性的独立思考能力，较强的定量技能，注重严谨性和可重复性，科学性 沟通和指导。MBTG为学生提供了UCSD关键的跨学科“家” 以及对分子生物物理学感兴趣的教师。高质量的学生出版物，博士后奖学金， 我们的学员获得的教师职位和行业职位是成功培训的有力证据 结果。鉴于我们学生库的深度，质量和多样性以及我们展示的培训成果，我们 每年资助12名学生。

项目成果

Targeted protein degradation: Emerging concepts and protein state-specific targeting principles.

• DOI: 10.1016/j.cbpa.2021.102114
• 发表时间: 2022-04
• 期刊: Current opinion in chemical biology
• 影响因子: 7.8

Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.

• DOI: 10.1126/sciadv.adk6191
• 发表时间: 2023-12
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Sanz Murillo, Marta;Villagran Suarez, Amalia;Dederer, Verena;Chatterjee, Deep;Alegrio Louro, Jaime;Knapp, Stefan;Mathea, Sebastian;Leschziner, Andres E.
• 通讯作者: Leschziner, Andres E.