Molecular Biophysics Training Grant at UC San Diego

加州大学圣地亚哥分校分子生物物理学培训补助金

• 批准号: 10615137
• 负责人: ELIZABETH A. KOMIVES
• 金额: $ 49.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615137
• 关键词: Biophysics; Grant; Molecular; Training

ABSTRACT. The goal of the Molecular Biophysics Training Grant (MBTG) at the University of California San Diego is to provide a rigorous and strongly interdisciplinary training program for graduate students, with the aim of training the next generation of scientific leaders striving to solve important biological problems using Molecular Biophysics approaches. To accomplish this goal, trainees with strong quantitative backgrounds and a demonstrated aptitude, commitment, and passion for research are selected at the end of their first year from a diverse group of applicants from 32 well-funded training faculty labs. The MBTG faculty are highly interdisciplinary and many have cross-campus appointments in several departments. Trainees come mostly from two graduate programs, Chem/Biochem and Biomedical Sciences but a few come from Physics, Biology and Bioengineering. During their first year, all students engage in research rotations and choose a research lab. At UCSD, students are free to rotate with any faculty across campus and to choose any faculty for their thesis advisor. First year students receive training from their respective graduate programs in critical reading of literature, exposure to important unsolved biological problems, ethics and graduate school survival skills. MBTG Trainees are appointed and choose their thesis committee at the end of their first year. All MBTG trainees take two rigorous core courses in Molecular Biophysics and will have an intensive week-long Statistics workshop. During their second year, they write and defend their thesis research proposal. Required trainee activities include a full-length seminar presentation of their research at the monthly student seminar, monthly discussions of rigor and reproducibility, a monthly journal club, a yearly retreat, career workshops and outside mentors. Trainees may apply to be reappointed for a maximum of two years of support. All trainees present their research every year at the annual retreat, with alumni trainees giving lightning talks each year until graduation. Throughout their graduate training, trainees take advantage of career development opportunities and mentorship, including yearly IDPs and group and individual engagement with outside mentors. The program emphasizes the development of creative independent thinking, strong quantitative skills with a focus on rigor and reproducibility, scientific communication, and mentoring. The MBTG provides the critical interdisciplinary “home” at UCSD for students and faculty interested in Molecular Biophysics. The high quality of student publications, postdoctoral fellowships, faculty positions, and industry positions obtained by our trainees are strong evidence of successful training outcomes. Given the depth, quality, and diversity of our student pool and our demonstrated training outcomes, we request 12 students be supported each year.

抽象的。加州大学圣何塞分校分子生物物理学培训补助金 (MBTG) 的目标 迭戈将为研究生提供严格的、强跨学科的培养计划，旨在 培训下一代科学领导者，努力利用分子解决重要的生物学问题 生物物理学方法。为了实现这一目标，具有强大定量背景和 表现出对研究的才能、承诺和热情是在第一年结束时从 来自 32 个资金充足的培训教师实验室的多元化申请人群体。 MBTG 的师资水平非常高 跨学科，许多人在多个部门有跨校园的任命。学员大多来自 两个研究生课程，化学/生物化学和生物医学科学，但也有一些来自物理、生物学和 生物工程。在第一年，所有学生都会进行研究轮换并选择一个研究实验室。在 加州大学圣地亚哥分校，学生可以自由地与校园内的任何教师轮换，并选择任何教师进行他们的论文 顾问。一年级学生接受各自研究生课程的批判性阅读培训 文学、接触重要的未解决的生物学问题、道德和研究生院生存技能。 MBTG 学员在第一年结束时被任命并选择他们的论文委员会。所有 MBTG 学员都参加 两门严格的分子生物物理学核心课程，并将举办为期一周的强化统计研讨会。 在第二年，他们撰写并答辩他们的论文研究计划。所需的实习生活动包括 在每月的学生研讨会上对他们的研究进行完整的研讨会介绍，每月进行严格的讨论 和可重复性、每月期刊俱乐部、每年一次静修、职业研讨会和外部导师。实习生 可以申请连任以获得最多两年的支持。所有学员每次都会展示他们的研究成果 在一年一度的静修会上，校友学员每年都会进行闪电演讲，直到毕业。整个他们的 研究生培训，受训者利用职业发展机会和指导，包括每年 国内流离失所者以及团体和个人与外部导师的互动。该计划强调发展 创造性的独立思考，强大的定量能力，注重严谨性和可重复性，科学性 沟通、指导。 MBTG 为学生提供 UCSD 重要的跨学科“家” 以及对分子生物物理学感兴趣的教师。高质量的学生出版物、博士后奖学金、 学员获得的教职和行业职位是培训成功的有力证据 结果。鉴于我们学生库的深度、质量和多样性以及我们所展示的培训成果，我们 要求每年资助 12 名学生。

项目成果

Targeted protein degradation: Emerging concepts and protein state-specific targeting principles.

• DOI: 10.1016/j.cbpa.2021.102114
• 发表时间: 2022-04
• 期刊: Current opinion in chemical biology
• 影响因子: 7.8

Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.

• DOI: 10.1126/sciadv.adk6191
• 发表时间: 2023-12
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Sanz Murillo, Marta;Villagran Suarez, Amalia;Dederer, Verena;Chatterjee, Deep;Alegrio Louro, Jaime;Knapp, Stefan;Mathea, Sebastian;Leschziner, Andres E.
• 通讯作者: Leschziner, Andres E.