Non-Enzymatic Sensing of Creatinine for Early Detection of Chronic Kidney Disease

肌酐的非酶感应用于慢性肾脏病的早期检测

• 批准号: 2903497
• 金额: --
• 依托单位: Lancaster University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2903497
• 关键词: Non; Enzymatic; Sensing; Creatinine; Early

In recent years, there has been a dramatic advancement of biochemical markers for kidney healthcare. Creatinine is a useful metabolite for the evaluation of Chronic Kidney Disease (CKD). Creatinine concentrations in urine <3 and >20 mM may indicate CKD. CKD can be detected earlier before the disease has progressed to further stages using a creatinine sensing platform. Early detection and monitoring can provide lifesaving intervention, and as such there is a need to develop rapid, cheap and highly selective electrochemical non-enzymatic creatinine sensors to overcome some of the limitations of state-of-the-art enzymatic creatinine biosensors or the long-established colorimetric Jaffe reaction method. Low cost, non-enzymatic sensing platforms were developed as part of the PhD.

近年来，肾脏保健的生化标志物有了显着的进步。肌酐是一种有用的代谢物，用于评估慢性肾脏病（CKD）。尿肌酐浓度&gt; <3 and >20 mM可能提示CKD。使用肌酐传感平台，可以在疾病进展到进一步阶段之前更早地检测到CKD。早期检测和监测可以提供挽救生命的干预，因此需要开发快速、廉价和高选择性的电化学非酶促肌酸酐传感器，以克服现有技术的酶促肌酸酐生物传感器或长期建立的比色Jaffe反应方法的一些局限性。低成本，非酶传感平台作为博士学位的一部分开发。