TRAUMA AND INJURY BIOLOGY RESEARCH TRAINING PROGRAM

创伤和损伤生物学研究培训计划

• 批准号: 7250035
• 负责人: K CRAIG Kent
• 金额: --
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7250035
• 关键词: Biology; Injury; Research Training; Training Programs; Trauma

DESCRIPTION (provided by applicant): The proposed Trauma and Injury Biology Research Training program is designed to provide a high quality, focused two year research experience for post-graduate MD's or Ph.D.'s expressing a commitment to a career in trauma and injury biology investigation. The majority of research mentors come from the Departments of Surgery, Medicine, Biochemistry, Cell Biology, Pharmacology and Pathology at Weill Medical College of Cornell University (WMC). Other participating institutions include: The Rockefeller University, Sloan-Kettering Institute and Albany Medical College. Research training is accomplished through four categories of experiences: 1) required core curriculum; 2) mentor-directed laboratory training in areas relevant to trauma and injury biology; 3) attendance at research-related seminars (both departmentally- and laboratory-based); and 4) attendance and presentation of scientific data at national scientific meetings and symposia. All Core Faculty preceptors have active, funded laboratories that will provide outstanding research opportunities for the trainees. The Trauma and Injury Biology Executive Committee provides administrative guidance to the Program Director evaluates program progress and trainee applications and suggests future programmatic efforts. All trainees will receive direct supervision in the performance, interpretation, and presentation of the data and will also be instructed in methods for manuscript and grant preparation. It is anticipated that graduates of this program will possess a sufficiently mature grasp of current research methods and issues to promote their continued evolution as successful independent investigators in trauma and injury biology.

描述（由申请人提供）：拟议的创伤和损伤生物学研究培训计划旨在为研究生医学博士或博士提供高质量，集中的两年研究经验。表达了对创伤和损伤生物学研究事业的承诺。大多数研究导师来自康奈尔大学威尔医学院（WMC）的外科，医学，生物化学，细胞生物学，药理学和病理学系。其他参与机构包括：洛克菲勒大学、斯隆-凯特琳研究所和奥尔巴尼医学院。研究培训通过四类经验完成：1）所需的核心课程; 2）导师指导的实验室培训，在创伤和损伤生物学相关领域; 3）参加与研究相关的研讨会（部门和实验室为基础）;和4）出席并在国家科学会议和研讨会上介绍科学数据。所有核心学院的导师都有活跃的，资助的实验室，这将为学员提供出色的研究机会。创伤和损伤生物学执行委员会为项目主任提供行政指导，评估项目进展和学员申请，并建议未来的项目努力。所有学员将在数据的表现，解释和演示方面接受直接监督，并将在手稿和赠款准备方法方面接受指导。预计该计划的毕业生将对当前的研究方法和问题有足够成熟的把握，以促进他们作为创伤和损伤生物学成功的独立研究者的持续发展。

项目成果

Gender affects macrophage cytokine and prostaglandin E2 production and PGE2 receptor expression after trauma.

性别影响创伤后巨噬细胞细胞因子和前列腺素 E2 的产生以及 PGE2 受体的表达。

• DOI: 10.1016/j.jss.2004.04.020
• 发表时间: 2004
• 期刊: The Journal of surgical research.
• 作者: Stapleton,PhilipP;Strong,VivianEMack;Freeman,TracyA;Winter,Jordan;Yan,Zhaoping;Daly,JohnM
• 通讯作者: Daly,JohnM

Parenteral nutrition alters monocyte TNF receptor activity.

肠外营养改变单核细胞 TNF 受体活性。

• DOI: 10.1006/jsre.1995.1127
• 发表时间: 1995
• 期刊: The Journal of surgical research.
• 作者: Braxton,CC;Coyle,SM;Montegut,WJ;vanderPoll,T;Roth,M;Calvano,SE;Lowry,SF
• 通讯作者: Lowry,SF

Upregulation of protein kinase cdelta in vascular smooth muscle cells promotes inflammation in abdominal aortic aneurysm.

血管平滑肌细胞中蛋白激酶 cdelta 的上调可促进腹主动脉瘤的炎症。

• DOI: 10.1016/j.jss.2008.04.032
• 发表时间: 2009
• 期刊: The Journal of surgical research
• 作者: Schubl,Sebastian;Tsai,Shirling;Ryer,EvanJ;Wang,Chunjie;Hu,June;Kent,KCraig;Liu,Bo
• 通讯作者: Liu,Bo

Beneficial effect of enteral glycine in intestinal ischemia/reperfusion injury.

肠内甘氨酸对肠道缺血/再灌注损伤的有益作用。

• DOI: 10.1007/s11605-006-0011-0
• 发表时间: 1997
• 期刊: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
• 作者: Iijima,S;Shou,J;Naama,H;Calvano,SE;Daly,JM
• 通讯作者: Daly,JM

Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans.

内毒素诱导人体循环单核细胞和粒细胞上肿瘤坏死因子受体的下调。

• 发表时间: 1995
• 期刊: Blood
• 影响因子: 20.3
• 作者: vanderPoll,T;Calvano,SE;Kumar,A;Braxton,CC;Coyle,SM;Barbosa,K;Moldawer,LL;Lowry,SF
• 通讯作者: Lowry,SF