Efficacy of Mindfulness-Based Relapse Prevention

基于正念的复发预防的功效

• 批准号: 7268048
• 负责人: Gordon ALAN Marlatt
• 金额: $ 18.4万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268048
• 关键词: Abstinence; Adherence; Affect; Aftercare; Alcohols; Area; Behavioral; Caring; Clinical Trials; Cognitive; Cognitive Therapy; Communities; Competence; Condition; Control Groups; Control Locus; County; Data; Development; Disease; Drug Use Disorder; Drug abuse; Drug usage; Enrollment; Future; General Population; Individual; Intervention; Investigation; Literature; Manuals; Measures; Mediating; Mediator of activation protein; Meditation; Mental Depression; Mental disorders; Mission; Modeling; Outcome; Outpatients; Participant; Pattern; Pharmaceutical Preparations; Population; Prevention; Prevention intervention; Prevention program; Prevention strategy; Probability; Process; Randomized Clinical Trials; Rate; Recovery; Recruitment Activity; Relapse; Research; Research Design; Research Personnel; Risk; Role playing therapy; Sampling; Self Efficacy; Staging; Substance abuse problem; Techniques; Testing; Thinking; Training; Treatment Efficacy; Work; alcohol and other drug; base; comparison group; coping; craving; disorder later incidence prevention; drug relapse; efficacy trial; follow-up; improved; innovation; interest; mindfulness based cognitive therapy; prevent; programs; size; skills; treatment effect; treatment program; volunteer

DESCRIPTION (provided by applicant): The broad, long-term objective of the current research is to improve treatment for alcohol and other drug (AOD) use disorders through development of an innovative alternative approach to preventing AOD relapse. The specific aims of the research are 1) To develop a manual and therapist adherence/competence measures to standardize delivery of a Mindfulness-Based Relapse Prevention (MBRP) program for post-treatment relapse prevention of AOD problems, which will be patterned after Mindfulness-Based Cognitive Therapy for Depression (Segal, Teasdale & Williams, 2002) and incorporate cognitive-behavioral relapse prevention strategies (Daley & Marlatt, 1997); 2) To conduct a pilot randomized clinical trial to assess the feasibility of recruiting and retaining individuals for a large scale study and to determine effect size of MBRP in comparison to cognitive-behavioral group relapse prevention based on Marlatt's Relapse Prevention model (RP) alone (Daley & Marlatt, 1997). Both MBRP and RP conditions will be compared to a treatment as usual control group (TAU) in a sample of participants enrolled in continuing care following Intensive Outpatient Treatment, at baseline, post-treatment, 2-, and 4-months following the baseline assessment; and 3) Evaluate potential mediators of MBRP and RP treatment efficacy. We hypothesize that both MBRP and RP will be more efficacious than TAU. We hypothesize MBRP efficacy will be mediated by meta-cognitive processes, thought suppression, locus of control, skills to cope with urges and cravings, negative affect and meditation practice. We hypothesize RP efficacy will be mediated by self-efficacy, negative affect and coping abilities. This research builds on over 25 years of developing and implementing RP interventions. MBRP incorporates specific alcohol and drug-focused cognitive therapy techniques with an additional emphasis on mindfulness skills, and builds upon the Investigator's prior work on meditation-based interventions.

描述(由申请人提供)： 当前研究的广泛、长期目标是通过开发一种预防AOD复发的创新替代方法来改善对酒精和其他药物使用障碍的治疗。这项研究的具体目标是：1)制定手册和治疗师的依从性/能力措施，以规范AOD问题治疗后复发预防的基于正念的复发预防(MBRP)计划的实施，该计划将仿效基于正念的抑郁症认知疗法(西格尔，泰斯代尔和威廉姆斯，2002)，并纳入认知-行为复发预防策略(Daley&Marlatt，1997)；2)进行一项试验性随机临床试验，以评估在大规模研究中招募和保留个体的可行性，并确定MBRP与仅基于Marlatt的复发预防模型(RP)的认知-行为群体复发预防的效果大小(Daley&Marlatt，1997)。将在基线、治疗后、基线评估后的2个月和4个月时，将MBRP和RP的情况与常规治疗对照组(TAU)进行比较；以及3)评估MBRP和RP治疗有效性的潜在中介因素。我们假设MBRP和RP都比TAU更有效。我们假设MBRP的有效性将通过元认知过程、思维抑制、控制点、应对冲动和渴望的技能、负面情绪和冥想练习来调节。我们假设RP效应将通过自我效能感、负面情绪和应对能力来调节。这项研究建立在超过25年的RP干预开发和实施的基础上。MBRP结合了特定的以酒精和药物为重点的认知治疗技术，并特别强调正念技能，并建立在研究者先前关于冥想干预的工作基础上。

项目成果

Mindfulness-based relapse prevention for substance craving.

• DOI: 10.1016/j.addbeh.2012.04.001
• 发表时间: 2013-02
• 期刊: ADDICTIVE BEHAVIORS
• 影响因子: 4.4
• 作者: Witkiewitz, Katie;Bowen, Sarah;Douglas, Haley;Hsu, Sharon H.
• 通讯作者: Hsu, Sharon H.

Relative efficacy of mindfulness-based relapse prevention, standard relapse prevention, and treatment as usual for substance use disorders: a randomized clinical trial.

• DOI: 10.1001/jamapsychiatry.2013.4546
• 发表时间: 2014-05
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Bowen, Sarah;Witkiewitz, Katie;Clifasefi, Seema L.;Grow, Joel;Chawla, Neharika;Hsu, Sharon H.;Carroll, Haley A.;Harrop, Erin;Collins, Susan E.;Lustyk, M. Kathleen;Larimer, Mary E.
• 通讯作者: Larimer, Mary E.

Depression, craving, and substance use following a randomized trial of mindfulness-based relapse prevention.

• DOI: 10.1037/a0019172
• 发表时间: 2010-06
• 期刊: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
• 影响因子: 5.9
• 作者: Witkiewitz, Katie;Bowen, Sarah
• 通讯作者: Bowen, Sarah

Mindfulness-based relapse prevention for substance use disorders: a pilot efficacy trial.

• DOI: 10.1080/08897070903250084
• 发表时间: 2009-10
• 期刊: Substance abuse
• 影响因子: 3.5
• 作者: Bowen S;Chawla N;Collins SE;Witkiewitz K;Hsu S;Grow J;Clifasefi S;Garner M;Douglass A;Larimer ME;Marlatt A
• 通讯作者: Marlatt A