Germinal centres, rogue B cells and the genesis of immunological diseases.

这项研究将确定免疫系统通常是如何防止产生针对人体自身细胞的自身抗体的，以及这种抗体在狼疮等自身免疫性疾病中是如何失效的。对一种新发现的“流氓”白色血细胞的有针对性的研究也将为自身免疫性疾病的发生提供新的线索。此外，通过CRISPR/Cas9诱变在小鼠中建立人类免疫性疾病的模型将为其病因和潜在治疗提供有价值的新见解。

This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered 'rogue' white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.