B cell survival and responsiveness in health and disease

我是一名免疫学家，专注于确定B淋巴细胞--负责产生抗体的细胞--如何存活并参与体内的免疫反应。我通过使用特别设计的转基因小鼠来实现这一点，这些小鼠允许我跟踪体内的B淋巴细胞，并识别它们的关键遗传和外部控制。我的工作与疫苗开发以及某些自身免疫性疾病和B淋巴细胞癌的控制有关。

I am an immunologist focused on identifying how B lymphocytes, the cells responsible for producing antibodies, survive and participate in immune responses within the body. I achieve this by using specially designed, genetically modified, mice that allow me to follow B lymphocytes within the body and identify their key genetic and external controls. My work is relevant to vaccine development as well as the control of certain autoimmune diseases and B lymphocyte cancers.